Blood volume monitoring to adjust dry weight in hypertensive pediatric hemodialysis patients |
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Authors: | Cengiz Candan Lale Sever Mahmut Civilibal Salim Caliskan Nil Arisoy |
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Institution: | (1) Department of Pediatric Nephrology, Istanbul University Cerrahpasa Medical Faculty, 34303 Kocamustafapasa, Istanbul, Turkey |
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Abstract: | The aim of this study was to adjust dry weight by short-term blood volume monitoring (BVM)-guided ultrafiltration and evaluate
the effects of optimizing dry weight on blood pressure (BP) control and intradialytic symptoms (IDS) in a group of hypertensive
hemodialysis (HD) patients. The study was performed in four sequential phases, each of which lasted for 1 week, on nine hypertensive
HD patients (six girls, age 16.9 ± 3.1 years). In phase I, patients were observed by BVM. In phase II, BVM was used to guide
ultrafiltration to adjust dry weight. Antihypertensive drugs were gradually tapered or withheld in phase III, when the patients
were hypotensive and/or their IDS increased. In phase IV, this particular weight was maintained without any intervention.
Pre- and post-HD body weight, pre-HD, post-HD, 30 min after HD casual BP values, and IDS in each HD session were recorded.
The BP was also assessed by 44-h ambulatory BP monitoring (ABPM), which is an ideal method to determine BP changes throughout
the interdialytic period at the beginning of phase I and at the end of phase IV. There was a decrease in mean dry weight,
all casual systolic BPs, and systolic/diastolic ABPM at the end of the study (all p ≤ 0.05). Antihypertensive drugs were stopped in five patients and reduced in two during phase III of the study. The IDS was
more frequent (36%) in phase IV than in phase I (16%); however, this increase did not reach statistical significance. The
results of this study suggest that short-term BVM guided-ultrafiltration may be a useful tool to diagnose volume overload
and to adjust dry weight and, consequently, to achieve a better control of BP in pediatric HD patients. |
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Keywords: | Ambulatory blood pressure monitoring Blood volume monitoring Dry weight Hypertension Pediatric hemodialysis |
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