| 康泰复方对D-IBS患者结肠黏膜HO-1和iNOSmRNA表达的影响 |
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| 引用本文： | 于丰彦,陶双友,罗琦,周福生,廖荣鑫.康泰复方对D-IBS患者结肠黏膜HO-1和iNOSmRNA表达的影响[J].海南医学,2010,21(10):9-12. |
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| 作者姓名： | 于丰彦 陶双友 罗琦 周福生 廖荣鑫 |
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| 作者单位： | 1. 南方医科大学珠江医院,广东广州,510280
2. 广州中医药大学脾胃研究所,广东,广州,510405 |
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| 基金项目： | 广东省中医药管理局科研课题 |
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| 摘 要： | 目的观察疏肝健脾安神和胃法的康泰方对肝郁脾虚型D-IBS患者治疗前、后结肠黏膜HO-1和iNOSmRNA的表达的影响,从结肠粘膜HO-1和iNOSmRNA的方面初步探讨康泰方治疗D-IBS的可能机制。方法采用随机分组法将63例受试对象分为治疗组（32例）和对照组（31例）,观察治疗前、后结肠粘膜HO-1和iNOSmRNA表达的变化,并分别与15例健康对照组进行比较。结果治疗组治疗前、后HO-1和iNOSmRNA的表达差异有统计学意义（P〈0.05）,对照组治疗前、后的HO-1和iNOSmRNA的表达差异亦有统计学意义（P〈0.05）。结论结肠黏膜HO-1和iNOSmRNA表达可能是其临床表现的致病机理,康泰方可通过上述机理改善临床症状。
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| 关 键 词： | 肝郁脾虚型 D-IBS HO-1mRNA iNOSmRNA |
Effect of kangtai on the HO - 1 and iNOS mRNA in colonic mucosa with D - IBS |
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| Institution: | YU Feng-yan,TAO Shuang-you,LUO Qi,et al.Zhujiang Hospital Affiliated to the South Medical University,Guangzhou 510280,Guangdong,CHINA |
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| Abstract: | Objective To observe the effect of kangtai on the HO-1 and iNOS mRNA in colonic mucosa with D-IBS.Methods 63 cases were randomly divided into the treatment group and the control group,and the treatment group and control group had been treated with kangtai,and pinaverium bromide tablets for 8 weeks,respectively.The expression of HO-1 and iNOS mRNA were detected in colonic mucosa before and after treatment.Results There was a significant difference of the expression of HO-1 and iNOS mRNA in colonic mucosa between before and after treatment.Conclusion The expression of HO-1 and iNOS mRNA in colonic mucosa may be the pathogenesis of D-IBS,and kangtai can improve symptoms via the above-mentioned mechanisms. |
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| Keywords: | D-IBS HO-1 mRNA iNOS mRNA |
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