重症肌无力病人危象82例临床分析

目的 探讨重症肌无力（MG）危象的诱发因素、延长气管插管的因素以及并发症、病死率。方法 回顾性分析了82例MG病人（87次危象）的年龄、性别、发病年龄、诱发因素、气管插管并发症及影响插管时间的因素。结果 75％病人存在诱发危象的因素，其中感染为常见因素，其次外伤、劳累、月经及分娩，医源性因素占24％。有9个因素延长气管插管。12例死亡，病死率为14％。结论 积极治疗及预防肌无力危象病人气管切开后并发症，可有效缩短气管插管的时间，降低病死率。

Clinical analysis of 82 patients with myasthenic crisis

Objective To evaluate the precipitating factor,mortality,complications of myasthenia gravis crisis and risk factors of prolonged intubation.Methods Totally 82 case records of patients who had been adimitted for having 87 episodes of myasthenia crisis over a period of 15 years from January 1985 to February 2000 and their age, gender, precipitating factors, complications of intubation, and prolonged intubation factors were retrospectively reviewed. Results In 75% of myasthenic crisis patients having precipitating factors, infection was the most often served as the precipitating factors, and then the wound, fatigue, manopause and delivery came the next, 24% of precipitating factors were related to medication. Nine were identified with independent predictors of prolonged intubation. Among the 82 myasthenia crisis patients, 12 died, with a mortality of 14%.Conclusion The prevention and treatment for intubation complications may be the best way for further shortening intubation time and reducing the mortality.