|
|||||
|
|
Clinical Study of Cyclocytidine in Children With Acute Leukemia |
|
| Authors: | ISE, TOHRU OHTSUKI, HIROSHI AKATSUKA, JUNICHI TSUKIMOTO, ICHIRO HANAWA, YOSHIYUK.I NAGAO, TAKESHI ISHIKAWA, AKIRA KOIDE, RYO TAGUCHI, NOBUYUKl KUDO, HTSAO MATSUYAMA, SHUSUKE NISHIMURA, KOZO OHMI, KEIKO SHIKE, SEIJCHIRO UEDA, YUTAKA YOSHLKAWA, TOSHIO |
| Affiliation: | 1Department of Pediatrics National Cancer Center Hospital, Tokyo 2Department of Pediatrics National Cancer Center Hospital, Tokyo 3Department of Pediatrics Jikei University, School of Medicine, Tokyo 4Department of Pediatrics Toho University Hospital, Tokyo 5Department of Oncology and Hematology Kanagawa Children's Medical Center, Yokohama 6Department of Oncology and Hematology Kanagawa Children's Medical Center, Yokohama 7Department of Pediatrics Showa University, School of Medicine, Tokyo 8Department of Hematology National Children's Hospital, Tokyo 9Department of Hematology National Children's Hospital, Tokyo 10Department of Pediatrics Kyorin University, School of Medicine, Tokyo 11Department of Pediatrics Yokohama City University, School of Medicine, Yokohama 12Department of Pediatrics St. Luke's Tfi-ternational Hospital, Tokyo 13Department of Pediatrics University of Tokyo, Faculty of Medicine, Tokyo 14Department of Pediatrics University of Tokyo, Faculty of Medicine, Tokyo 15Department of Pediatrics Nippon Medical School, Tokyo 16Department of Pediatrics Juntendo University, School of Medicine, Tokyo |
| Abstract: | One hundred children with various types of leukemia were given113 treatments with cyclocytidine. Eighty-four of these patientshad been treated previously. Cyclocytidine was daily given intravenouslyfor four to 11 consecutive days in amounts of 20mg/kg or 500mg/m2.The treatment course . was repeated, when necessary. Complete remission was obtained in one case of monocytic leukemiaamong six treated by cyclocytidine alone. Combined therapy withsteroid hormone gave 14 complete and eight partial remissionsin 38 cases, the remission rate standing at 58%. There were30 complete and 16 partial remissions in 69 cases treated withcombination therapy with two or more agents, and the remissionrate was 67%. Transient pains in the region of the parotid gland were themost characteristic toxicity. GI tract symptoms were less commonand milder than those of cytosine arabinoside. Dizziness wasnoticed in three cases. Nine children with acute leukemia who were given cyclocytidineorally showed no remarkable response. Cyclocytidine, given parenterally, seems beneficial for varioustypes of leukemia in children. |
| Keywords: | |
| 本文献已被 Oxford 等数据库收录！ | |