恶性黑色素瘤选择性表达孕激素受体并与PCNA呈负相关性

目的探讨孕激素受体(PR)在恶性黑色素瘤(MM)中的表达情况及意义。方法以免疫组化法检测35例MM患者标本,8例痣细胞痣PR及增殖性细胞核抗原(PCNA)的表达,并结合临床及组织病理学资料进行分析。结果在MM中PR的阳性表达率为25.7%,在痣细胞痣中无表达。MM中PR表达与PCNA表达显著负相关。女性、年龄≤55岁、病程>1年、溃疡以及非肢端型组织亚型PR阳性比例增高,但均无统计学意义。结论PR在MM中选择性表达并可能具有抗增殖作用。

Selective Expression of Progesterone Receptor in Malignant Melanoma Reversely Correlated with PCNA

Objective To investigate the role of progesterone receptor(PR)expression in malignant melanoma(MM).Methods PR and proliferative cell nuclear antigen(PCNA)expression in a series of 40 specimens from 35 patients with MM were evaluated by immunohistochemistry,and the correlation between the immunohistochemistry findings and clinicohistopathology date was also analyzed.Results PR expression was 25.7%(9/35)of MM.No PR expression was observed in nevi.PR expression was significantly inversely correlated with PCNA expression.There was a slight increasing of PR expression in female,aged less than 55 years,diagnosis delay longer than 1 year,ulceration and non-acral histopathology subtype,but not reaching statistic significance.Conclusion Selective expression of progesterone receptor in malignant melanoma correlated with tumor growth inhibition.