| 结肠癌患者血清MCP-1含量的检测及其意义 |
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| 引用本文： | 孙力超,李树婷,孙立新,遇珑,韩璐璐,刘彤,杨治华,冉宇靓.结肠癌患者血清MCP-1含量的检测及其意义[J].中国卫生检验杂志,2011(3). |
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| 作者姓名： | 孙力超 李树婷 孙立新 遇珑 韩璐璐 刘彤 杨治华 冉宇靓 |
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| 作者单位： | 中国医学科学院北京协和医学院肿瘤研究所分子肿瘤学国家重点实验室;中国医学科学院肿瘤医院内科; |
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| 基金项目： | 国家重点基础研究发展计划(973)资助项目(2009CB521804)~~ |
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| 摘 要： | 目的:研究结肠癌患者外周血中单核细胞趋化蛋白1(MCP-1)水平的变化,探讨其临床意义。方法:采用酶联免疫吸附法(ELISA)分别测定98例结肠癌患者(37例未发生肝转移\61例发生肝转移)和40例正常人(对照组)血清MCP-1的水平,并进行比较。结果:发生肝转移结肠癌患者血清MCP-1水平为(158.7±267.4)pg/ml,未发生肝转移结肠癌患者血清MCP-1水平为(78.3±116.1)pg/ml,正常对照组血清MCP-1水平为(57.1±48.8)pg/ml。临床相关性发现血清MCP-1水平与肝转移、临床分期相关。结论:MCP-1在结肠癌肝转移中起重要作用,监测血清MCP-1水平可反映结肠癌的进展程度,具有重要的临床价值。
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| 关 键 词： | 结肠癌 单核细胞趋化因子-1 |
Clinical significance of serum monocyte chemoattractant protein-1 level in colon cancer patients |
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| SUN Li-chao,LI Shu-ting,SUN Li-xin,YU long,HAN Lu-lu,LIU Tong,YANG Zhi-hua,RAN Yu-liang,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,People's Republic of China,Beijing ,China,.Internal Medicine,China.Clinical significance of serum monocyte chemoattractant protein-1 level in colon cancer patients[J].Chinses Journal of Health Laboratory Technology,2011(3). |
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| Authors: | SUN Li-chao LI Shu-ting SUN Li-xin YU long HAN Lu-lu LIU Tong YANG Zhi-hua RAN Yu-liang Chinese Academy of Medical Sciences Peking Union Medical College Beijing People's Republic of China Beijing China Internal Medicine China |
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| Institution: | SUN Li-chao1,LI Shu-ting2,SUN Li-xin1,YU long1,HAN Lu-lu1,LIU Tong1,YANG Zhi-hua1,RAN Yu-liang1(1.State Key Laboratory of Molecular Oncology,Cancer Institute(Hospital),Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing,People's Republic of China,Beijing 100021,China,2.Internal Medicine,China) |
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| Abstract: | Objective:To study the level of monocyte chemoattractant protein 1(MCP-1) in peripheral blood in colon cancer patients with or without liver metastasis and normal people and to explore its clinical significance.Methods:Using enzyme-linked immunosorbent assay were measured in 98 cases of colon cancer patients(37 colon cancer patients without liver metastasis/61 ones with liver metastasis) and 40 healthy people(control group) serum levels of MCP-1,and compared.Results:The serum level of MCP-1 in colon cancer ... |
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| Keywords: | Colon cancer Monocyte chemoattractant protein-1 Liver metastasis |
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