妊娠糖尿病使用门冬胰岛素与普通人胰岛素治疗对围产期影响的临床研究

目的:比较胰岛素类似物门冬胰岛素与普通人胰岛素治疗妊娠糖尿病妇女的围产期结果。方法:将62例新诊断的饮食控制不达标的妊娠糖尿病妇女随机分为使用门冬胰岛素治疗组(Asp组)及使用普通人胰岛素治疗组(HI组),观察分娩时胰岛素用量(U/(kg.d))、羊水量(ml)、胎儿出生时体重(g)和身长(cm)、以及空腹及餐后血糖(mmol/L)、低血糖事件发生数等指标。结果:①Asp组分娩时羊水量显著低于HI组(417.0±13.2 ml vs 989.7±29.3 ml;P<0.05);同时Asp组餐后血糖显著低于HI组(6.5±0.4 mmol/L vs 9.3±1.5 mmol/L;P<0.05)。Asp组总计发生低血糖事件数为58次,而HI组总计发生低血糖事件数为203次。②羊水量与餐后血糖控制程度有正相关关系(r=0.72,P<0.05)。结论:门冬胰岛素能很好的控制餐后血糖,减少围产期羊水过多、巨大儿等风险,且能减少低血糖事件。

Gestational diabetes using insulin aspart and insulin therapy on perinatal ordinary clinical study on effects

Objective:To assess the results of insulin aspart in comparison with regular human insulin in women with gestational diabetes mellitus(GDM) during perinatal stage.Methods: 62 women with newly diagnosed GDM who had inadequate diabetes control with diet alone were randomly divided into two groups,and they were received therapy with aspart insulin or human insulin.Insulin doses,the volume of amniotic fluid,weight and length of neonates,fasting plasma glucose and postprandial plasma glucose,hypoglycemia were re...