| 2型糖尿病患者慢性肾脏病和蛋白尿的相关性分析 |
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| 引用本文： | 徐旭,梁国威,刘耘.2型糖尿病患者慢性肾脏病和蛋白尿的相关性分析[J].中国卫生检验杂志,2011(5). |
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| 作者姓名： | 徐旭 梁国威 刘耘 |
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| 作者单位： | 航天中心医院检验科; |
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| 摘 要： | 目的:探讨2型糖尿病(DM2)患者中1、2级慢性肾脏病(CKD1、CKD2)和蛋白尿的相关性。方法:对591例(男性:438例;女性:153例)DM2人群进行和断面调查。采用简化MDRD公式估算肾小球滤过率(eGFR)划分CKD1和CKD2。通过随机尿中白蛋白与肌酐比值(ACR,mg/g)确定蛋白尿。结果:CKD1组无蛋白尿、微量蛋白尿、大量蛋白尿的发生率分别为78.9%、18.1%和3.0%,CKD2组分别为63.4%、24.8%和11.8%。控制年龄、性别、糖尿病病程、体重指数、血压、血脂、空腹血糖和糖化血红蛋白,Logistic回归分析显示,微量蛋白尿较无蛋白尿的糖尿病患者发生CKD2危险性的OR(95%CI)值是3.06(1.19-7.84)倍;大量蛋白尿较无蛋白尿的糖尿病患者发生CKD2危险性的OR值是6.00(2.43-14.78)倍。结论:蛋白尿与CKD的发展联系紧密,是CKD1发展为CKD2的独立危险因素。
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| 关 键 词： | 2型糖尿病 慢性肾脏病 尿白蛋白排泄率 |
Association between urine albumin to creatinine ratio and chronic kidney disease in type 2 diabetic patients |
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| XU Xu,LIANG Guo-wei,LIU Yun.Association between urine albumin to creatinine ratio and chronic kidney disease in type 2 diabetic patients[J].Chinses Journal of Health Laboratory Technology,2011(5). |
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| Authors: | XU Xu LIANG Guo-wei LIU Yun |
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| Institution: | XU Xu,LIANG Guo-wei,LIU Yun(Department of Clinical Laboratory,Aerospace Center Hospital,Beijing 100049,China) |
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| Abstract: | Objective:The aim of this study was to explore the relationship between chronic kidney disease(stage 1 and stage 2,CKD1 and CKD2) and urine albumin to creatinine ratio(ACR) in type 2 diabetic patients.Methods: A total of 591 type 2 diabetic patients(438 men,153women) were enrolled in the cross-sectional survey.The CKD was divided into CKD1 and CKD2 according to the estimated estimating Glomerular Filtration Rate(eGFR)calculated by the MDRD study equation.Random Urine samples were examined for urine albumin ... |
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| Keywords: | Type 2 diabetic mellitus Chronic kidney disease Urine albumin to creatinine ratio |
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