| 阿折地平对自发性高血压火鼠心肌细胞凋亡的影响 |
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| 引用本文： | 胡莲芬,刘光德.阿折地平对自发性高血压火鼠心肌细胞凋亡的影响[J].中国现代医生,2010,48(4):29-31. |
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| 作者姓名： | 胡莲芬 刘光德 |
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| 作者单位： | 广东省珠海市人民医院心血管内科,广东珠海,519000 |
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| 摘 要： | 目的探讨阿折地平对自发性高血压大鼠心肌细胞凋亡的影响。方法将自发性高血压大鼠随机分为治疗组阿折地平3mg／（kg·d）溶于生理盐水中灌胃]、SHR组，另选WKY大鼠为正常对照组，每组10只。分别每周测大鼠血压，10周后处死测其左心室肥厚指数，计数细胞凋亡数，ELISA法检测心肌细胞TNF-α的表达。结果SHR组与WKY组血压无明显改变，治疗前后比较亦无明显差异（P〉0．05），治疗组的血压较治疗前显著降低（P〈0．01），与WKY组比较无明显差异，治疗组左心室肥厚指数、细胞凋亡指数及TNF—α的表达显著小于SHR组（P〈0．01），治疗组与WKY组比较无显著性差异（P〉0．05）。结论阿折地平能有效的控制血压，能有效的抑制高血压所致的左心室肥厚、细胞凋亡及心肌TNF-α的表达。
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| 关 键 词： | 阿折地平 细胞凋亡 大鼠 |
Effects of Azelnidipine on Cardiomyocyte Apoptosis of Spontaneously Hypertensive Rats |
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| Authors: | HU Lianfen LIU Guangde |
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| Institution: | HU Lianfen LIU Guangde Department of Cardiology,Zhuhai Municipal People\'s Hospital,Zhuhai 519000,China |
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| Abstract: | Objective To explore the effect of Azelnidipine on cardiomyocyte apoptosis of spontaneously hypertensive rats(SHR) . Methods Twenty SHRs were randomly divided into 2 groups(treatment group and SHR group,with 10 rats in each) and treated with Azelnidipine for 10 weeks and control group(10 WKY rats) was treated with 0.9% sodium chloride solution.The rat blood pressure was measured every week. The rats were sacrificed after 10 weeks,the left ventricular hypertrophy index was measured,the number of cell apoptos... |
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| Keywords: | Azelnidipine Apoptosis Rat |
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