Altered distribution of urinary glycosaminoglycans in diabetic subjects |
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Authors: | D. Juretić V. Krajnović J. Lukač-Bajalo |
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Affiliation: | (1) Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, University of Zagreb, Domagojeva 2, 10000 Zagreb, Croatia, HR;(2) General Hospital “Dr. Josip Benčević”, Medical-Biochemical Laboratory, Slavonsky Brod, Croatia, HR;(3) Faculty of Pharmacy, Section of Clinical Biochemistry, University of Ljubljana, Ljubljana, Slovenia, SI |
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Abstract: | We studied the influence of type 1 and type 2 diabetes mellitus with similar duration on the urinary excretion of total glycosaminoglycans and alteration of urinary glycosaminoglycan distribution pattern. Investigations were performed in the 24-hour urine samples of 31 children with type 1 diabetes mellitus, 36 adults with type 2 diabetes mellitus and in 30 age-matched controls for each group. We found that type 2 diabetes mellitus also induced an increased urinary excretion of total glycosaminoglycans and that both type 1 and type 2 diabetes alter the urinary distribution of heparan sulphate and dermatan sulphate. Observed changes correlate with duration of the disease. Microalbuminuria was detected in 9 of 36 type 2 adult diabetics (25%). The microalbuminic group had a significanlty higher heparan sulphate and/or dermatan sulphate excretion rate. To clarify whether an altered urinary distribution of heparan sulphate and dermatan sulphate may precede the development of microalbuminuria, it is necessary to performed a prospective study in which urinary glycosaminoglycans and microalbuminuria are measured year by year starting from the diagnosis of diabetes. Received: 23 August 2001 / Accepted in revised form: 3 April 2002 |
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Keywords: | Diabetes Glycosaminoglycans Heparan sulphate Dermatan sulphate Proteoglycans Microalbuminuria |
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