早期乳腺癌腋淋巴结转移的高危因素

目的 探讨早期乳腺癌淋巴结转移(ALNM)的高危因素.方法 收集乳腺癌病例156例,建立数据库,用Logistic回归进行多因素分析,并对有意义的指标进行相关分析,对其中的53例患者523枚阴性腋淋巴结再切片,用CK19行免疫组织化学染色.结果 多因素分析显示肿瘤大小、肿瘤部位、癌抗原153(CA153)、人类表皮生长因子受体-2(HER2)4个指标进入Logitic回归方程.53例患者中有4例患者的腋窝淋巴结CK19免疫组织化学染色体阳性.结论 肿瘤大小、肿瘤部位,CA153和HER2为乳腺癌患者ALNM的高危因素;CK19免疫组织化学染色可发现乳腺癌腋淋巴结微转移癌.

High dangerous factors analysis of axillary lymph node metastases in patients with early breast cancer and it's prognosis

Objective To study the High dangerous factors of axillary lymph node metastases(ALNM) of early breast cancer. Methods 156 breast cancer patients were collected to set up the database multi-factors logistic regression and then correlation analysis were used to evaluate the factors concerned.The 523 ALNs of 53 cases that were tumor negative in conventional. HE staining was further evaluated using immunohistochemical stains for CK19 antibody. Results Multi-factors logistic regression analysis showed that 4 factors including diameter of primary tumor,location of tumor,HER2,CA153 entered the logistic equation. There were 4 cases whose ALNs were reactive to immunostain for CK19 antibody amony 53 cases whose ALNs were negative for HE stain. Conclusions Diameter of primary tumor ,Location of tumor,HER2,CA153 were the risk factors of ALNM.Immunohistochemical staining can increase the detection rate of lymph node micrometastases.