伏隔核毁损术戒毒术前及术后心理学量表测评结果分析

目的 探讨伏隔核定向毁损术戒毒对智力、记忆、人格特征及焦虑情绪的影响。方法 采用中国修订韦氏成人智力量表、韦氏记忆量表、明尼苏达多项人格调查表、卡特尔16种个性因素测验及汉密顿焦虑量表对272例接受了手术的药物依赖、成瘾患者进行手术前后测评比较。结果 术后1个月及3个月未发现手术对智力、记忆有不良影响，且言语智商、操作智商和记忆商均较术前有明显改善（P〈0．01）；术后疑病、抑郁、癔病、精神病态评分明显减少（P〈O．01），偏执、精神分裂、轻躁狂评分明显增加（P〈0．01）；患者术后人格多种因素无显著改变，只有H、L、0、Q2和适应焦虑分增高（P〈0．05）；术后躯体性焦虑分数、精神性焦虑分数及焦虑总分均比术前显著降低（P〈O．01）。结论 定向伏隔核毁损术对患者智力和记忆水平无明显不良影响，部分功能较术前有所改善：可能对患者的部分个性特征如独立性、敢为性、忧虑性、怀疑性等构成一定影响。手术可使患者焦虑水平明显降低。

Analysis of Results of Psychological Scales before and after Stereotactically Ablating Nucleus Accumbens in patients with Drug Abstinence

Objective To explore the effects of ablating nucleus accumbens on intelligence, memory, characteristic of personality and anxiety emotion in the patients with drug abstinence. Methods The intelligence, memory, characteristic of personality and anxiety emotion were determined respectively by Wechsler adult intelligence scale-revised in China, Wechsler memory scale, Minnesota multi-phasic personality inventory, Cattell 16 personality factors and Hamilton anxiety scale before and after stereotactical ablation of nuclei accumbers and analysed in 272 patients with drug abstinence. Results There were insignificant difference in intellectuality and memory before and after the operation. The intelligence quotient and memory quotient were significantly improved after the operation compared to those before the operation (P<0.01). The scores of hypochondriasis, depression, hysteria and psychopathic deviate were significantly lower after the operation than those before the operation (P<0.01), while the scores of paranoid, schizoid and hypomania were signifi-cantly higher after the operation than those before the operation (P<0.01). There were insignificantly effect of the operation on persona-lity characteristic in general, but scores of H, L, O, Q2, adopt and anxiety were significantly increased after the operation (P<0.05). The scores of physical anxiety, psychological anxiety and general anxiety were significantly lower after the operation than those before the operation (P<0.01). Conclusion Ablating bilateral nuclei accumbens is of insignificant effect on intelligence and memory, and it produces the improvement in the some functions in the patients with drug abstinence. The operation may affect some of personality characteristics such as independence, boldness, disturbance and suspicion, and can decrease the level of anxiety of the patients.