The reepithelialization of rabbit cornea following single and multiple denudation |
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| Authors: | B D Srinivasan K E Eakins |
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| Affiliation: | 1. Department of Ophthalmology, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A.;2. Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, N.Y. 10032, U.S.A. |
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| Abstract: | The reepithelialization of rabbit corneas completely denuded once by abrasion with a dental stone was compared with the rate of reepithelialization of the contralateral eye following repeated but gentle repeeling of the epithelium at 2-day intervals for 6 days after an initial complete denudation by abrasion. Two or three times repeeled corneas showed a more rapid initial reepithelialization than observed after the first denudation. Polymorphonuclear leukocytes (PMNs) were found in the corneal stroma and tear fluid following both single and repeated denudation, but only up to 24 hours after the first, more traumatic, denudation were large numbers of PMNs found adherent to the exposed basement membrane of the corneal epithelium. It was hypothesized that PMNs on the corneal surface may interfere with reepithelialization. |
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| Keywords: | corneal denudation corneal epithelium polymorphonuclear leukocytes inflammation corneal reepithelialization |
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