| 痛风灵微丸处方药物组合优化的步骤与方法 |
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| 引用本文： | 冯乾坤,张 倩,李雪婷,王 沛.痛风灵微丸处方药物组合优化的步骤与方法[J].中国实验方剂学杂志,2010,16(2):87-89. |
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| 作者姓名： | 冯乾坤 张 倩 李雪婷 王 沛 |
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| 作者单位： | 长春中医药大学,吉林长春,130117 |
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| 基金项目： | 吉林省中医药管理局课题(08sys-033) |
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| 摘 要： | 目的:对治疗痛风病疗效确切的院内制剂痛风灵微丸的处方结构进行优化研究,为其临床前研究提供疗效可靠的优化处方,探索中药复方定量优化方法。方法:运用均匀设计改良法,以特异的药效学指标为评价指标,进行处方最佳配伍和最佳剂量配比的研究。结果:以均匀设计法得出痛风灵微丸的最佳配伍和最佳剂量配比的处方值。结论:该实验研究将拆方分析方法与最佳剂量配比研究结合起来,得到了比实践少1味药物的结论,并推荐其用于新药开发研究。
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| 关 键 词： | 痛风灵 微丸 均匀设计 药物组合优化 |
| 收稿时间： | 6/5/2009 12:00:00 AM |
Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats |
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| REN Jun-guo,MA Xiao-bin,LIN Cheng-ren,WANG Yang-hui,LI Hong-hai,WANG Min,LI Jun-mei and LIU Jian-xun.Protective Effect of Jiawei Shengmaisan Against Acute Myocardial Ischemia/Reperfusion Injury in Rats[J].China Journal of Experimental Traditional Medical Formulae,2010,16(2):87-89. |
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| Authors: | REN Jun-guo MA Xiao-bin LIN Cheng-ren WANG Yang-hui LI Hong-hai WANG Min LI Jun-mei and LIU Jian-xun |
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| Institution: | Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;Center for Experimental Research,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China |
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| Abstract: | |
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| Keywords: | Jiawei Shengmaisan Shengmaisan myocardial ischemia/reperfusion injury |
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