龙骨，磁石对小鼠镇静催眠作用的研究

目的：研究龙骨、磁石水煎剂对小鼠镇静催眠作用，并对两者进行比较。方法：采用行为药理为方法观察并测定龙骨、磁石对小鼠最大耐受量，对小鼠自发活动及对阈下剂量和阈剂量戊巴比妥钠催眠作用的影响。结果：ip龙骨、磁石水煎剂200g/kg小鼠最大耐受量倍数为667，龙骨、磁石水煎剂50、25g/kg等均可显著减少小鼠自发活动，能明显增加阈下剂量戊巴比妥纳小鼠的入睡率，可显著缩短戊嘏比妥钠小鼠的入时间并能延长其睡眠时间。结论 1）龙骨、磁石均对小鼠具有镇静催眠的作用；2）同浓度时龙骨的镇静催眠作用强于磁石。

Study on Sedative AndHypnotic Effect of LONG GU and CI SHI

Objective:To study and compare the sedative and hypnotic effect of Long Gu and Ci Shi on mice.Methods:By calculating maximal tolerance,by observing the changes of spontaneous activity,by measuring the change of hypnotic action induced with pentobarbital in subthreshold or threshold doses,effects of Long Gu and Ci Shi were estimated in mice.Results:Being given intraperitoneally Long Gu and Ci shi 200g/kg,the maximal tolerance of mice was 667 times larger than that of human being.Compared with control group,Long Gu and Ci Shi(50g/kg,25g/kg ip) could remarkedly decrease the spontaneous motion,enhance the rate of falling asleep induced by sodium pentobabital(in subthreshold dose),reduce the latent period of falling asleep,and prolong the sleep time induced by sodium pentobabital(in suprathreshold dose).Conclusion:Long Gu and Ci Shi possess obviously sedative and hypnotic effects in mice,and these effects of Long Gu show somewhat stronger than that of Ci Shi.