| 用抗-(抗HBc)抗体在同系小鼠中诱导抗-抗Id抗体 |
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| 引用本文： | 周继文,杨守纯,左冬梅,许建华,罗清华. 用抗-(抗HBc)抗体在同系小鼠中诱导抗-抗Id抗体[J]. 细胞与分子免疫学杂志, 1991, 0(1) |
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| 作者姓名： | 周继文 杨守纯 左冬梅 许建华 罗清华 |
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| 作者单位： | 解放军传染病研究所，解放军传染病研究所，解放军传染病研究所，解放军传染病研究所，解放军传染病研究所 北京 100039，北京 100039，北京 100039，北京 100039，北京 100039 |
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| 摘 要： | 用单克隆抗-(抗HBc)抗体(抗-Id)免疫BALB/c鼠,诱生出具有与抗-HBc相同反应性的抗-抗Id抗体(Ab_3)。这种抗体在ELISA试验中可与HBc-Ag特异性反应,并能抑制单克隆抗-HBc与HBcAg的结合。表明我们建立的抗-H-Bc的抗Id能模拟HBcAg刺激小鼠产生免疫反应。
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| 关 键 词： | 抗-(抗-HBc) 抗-抗Id 抗体 单克隆 |
Anti-anti-idiotypic Antibodies Induced by Anti-idiotypic Antibodies to Anti-HBc in Syngenic Mice |
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| Zhou Jiwen,Yang Shouchun,Zuo Dongmei,Xu Jianhua and Luo Qinhua. Anti-anti-idiotypic Antibodies Induced by Anti-idiotypic Antibodies to Anti-HBc in Syngenic Mice[J]. Chinese journal of cellular and molecular immunology, 1991, 0(1) |
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| Authors: | Zhou Jiwen Yang Shouchun Zuo Dongmei Xu Jianhua Luo Qinhua |
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| Abstract: | To observe the response of mouse to anti-idiotypic antibody against anti-HBc, BALB/c mice were immunized with antibodies against ant-BHcId (Ab2). Anti-anti-Id (Ab3) specific for anti-HBc were induced. The antibodies (Ab3) and anti-HBc (Ab1) had similar reactivity to HBcAg. Anti-HBc was inhibited to bind to HBcAg by Ab3 in ELISA test. The results suggest that Ab2 established can mimic the epitope of HBcAg and induce the immune eraction in mice. |
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| Keywords: | McAb anti-idiotypic antibody to anti-HBc anti-anti-Id |
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