| 原发性高血压病人群ACE基因的多态性与血管损害相关性的研究 |
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| 引用本文： | 张强,辛培玲.原发性高血压病人群ACE基因的多态性与血管损害相关性的研究[J].高血压杂志,1999,7(2):128-130. |
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| 作者姓名： | 张强 辛培玲 |
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| 作者单位： | 泰山医学院心内科，福建省泉州市第一医院 |
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| 摘 要： | 目的探讨血管紧张素转化酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态性与中国原发性高血压（ＥＨ）人群血管并发症之间的关系。方法应用ＰＣＲ技术扩增位于ＡＣＥ基因第１６内含子的一基因片段，共检测ＥＨ患者２０４例和正常对照９６例。结果ＥＨ组ＤＤ、ＤＩ、Ｉ型基因的分布频率与对照组无显著性差异，但三期ＥＨ亚组ＤＤ型基因及Ｄ等位基因的分布频率高于正常对照组（Ｐ＜０．０１）。血浆ＡＣＥ活性与基因类型的关系为ＤＤ＞ＤＩ＞Ｉ。结论中国原发性高血压人群ＡＣＥ基因１６内含子插入／缺失多态性与其血管并发症密切相关。
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| 关 键 词： | 原发性高血压 血管紧张素转化酶 基因多态性 并发症 |
Relation Between Insertion/Deletion Polymorphism of ACE Gene and Vascular Complications in
Essential Hypertension |
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| ZHENG Qiang,XIN Peiling,PAN Guang,ZHANG Xianzhong,WANG
Shuguang\=.Relation Between Insertion/Deletion Polymorphism of ACE Gene and Vascular Complications in
Essential Hypertension[J].Chinese Journal of Hypertension,1999,7(2):128-130. |
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| Authors: | ZHENG Qiang XIN Peiling PAN Guang ZHANG Xianzhong WANG
Shuguang\= |
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| Abstract: | Objective \ To
study the relation between insertion/deletion polymorphism of ACE gene and vascular
complicatios in essential hypertension (EH) in Chinese. \ Methed \ The fragment located at
intron 16 of ACE gene were examined by PCR.\ Results \ No significant differences among the
three genotypes(DD, DI, II) were found between EH group and control, but the frequency of DD
genotype and D allele were significantly higher among EH stage subgroup than control
(P<0.01). Serum ACE activity in three genotypes were: DD>DI>II.\ Conclusion \ Deletion
polymorphism of ACE gene is associated with vascular complication of EH in Chinese.\= |
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| Keywords: | insertion/deletion polymorphism \ ACE gene \ hypertension \ vascular complication |
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