江门市新会区实施育龄妇女免费增补叶酸对神经管畸形与服药情况的影响

目的 探讨江门市新会区育龄妇女免费增补叶酸实施推广后围产儿病死及神经管畸形情况与孕产妇服用叶酸情况.方法 2011年4月至2013年4月向江门市新会区育龄妇女免费派放叶酸,通过统计分析并比较实施推广项目前后围产儿病死及神经管畸形情况,各年间孕产妇服用叶酸情况.结果 采用服药措施后,围产儿病死率也由采用服药措施前的0.65％下降到0.54％；神经管畸形由0.18％下降到0.04％,围产儿病死率与神经管畸形发生率改善情况显著优于采用服药措施前,差异有统计学意义（P＜0.05）; 2009年至2013年叶酸总服药率由23.5％上升至73.5％；叶酸全程服药依从率由12.7％上升至63.8％.2013年至4月叶酸总服药率与全程服药依从率显著高于2009年,差异有统计学意义（P＜0.05）.结论 实施推广育龄妇女免费增补叶酸措施后,明显降低围产儿病死率与神经管畸形发生率,叶酸总服用率与全程服药依从率均呈逐年上升趋势.

Influence of free folic acid supplement for women of childbearing age in Xinhui, Jiangmen on neural tube defects and medication compliance

Objective To study the perinatal death and neural tube defects after the implementation of free folic acid for women of childbearing age in Xinhui,Jiangmen.Methods Free folic acid was given to the women of childbearing age in Xinhui,Jiangmen from April 2011 to April 2013.Perinatal deaths and neural tube defects were statistically analyzed and compared before and after the project.Folic acid use by the women in different years were statistically analyze and compared.Results After the women took folic acid,perinatal mortality dropped from 0.65％ to 0.54％,the rate of neural tube defects dropped from 0.18％ to 0.04％,with statistical differences （P ＜ 0.05）; the usage rate of folic acid rose from 23.5％ in 2009 to 73.5％ in 2013,the rate of medication compliance of folic acid rose from 12.7％ in 2009 to 63.8％ 2013,with statistical differences（P ＜ 0.05）.Conclusions After the implementation of free folic acid for women of childbearing age,the perinatal mortality and the incidence of neural tube defects obviously decrease and the usage rates of folic acid and medication compliance rise year by year.