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Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus |
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| Authors: | Akihiro Inui Hitoshi Ogasawara Toshio Naito Iwao Sekigawa Yoshinari Takasaki Yasuo Hayashida Kenji Takamori Hideoki Ogawa |
| Institution: | (1) Department of General Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku Tokyo, 113-8421, Japan;(2) Department of Internal Medicine and Rheumatology, 2-1-1 Hongo, Bunkyo-ku Tokyo, 113-8421, Japan;(3) Department of Internal Medicine, Juntendo University Urayasu Hospital, Urayasu-shi Chiba, 279-0021, Japan;(4) Institute for Environmental and Gender Specific Medicine, 2-1-1 Tomioka, Urayasu-shi Chiba, 279-0021, Japan |
| Abstract: | To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE. |
| Keywords: | Estrogen Estrogen receptor RQ-PCR Systemic lupus erythematosus |
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