戊乙奎醚吸入治疗急性加重期COPD疗效观察

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性加重期患者吸入盐酸戊乙奎醚的疗效。方法:45例COPD患者随机分为对照组21例和治疗组24例,两组均予吸氧、抗感染、静脉滴注氨茶碱等治疗,治疗组另给予盐酸戊乙奎醚0.5ml加入生理盐水4ml雾化吸入,每天2次。两组均于治疗前及治疗7天后测定患者肺功能及动脉血气。结果:两组治疗前,肺功能及动脉血气均无明显不同(P>0.05);两组治疗后,肺功能及动脉血气较治疗前均有明显改善(P<0.01);治疗组与对照组比较,第一秒用力呼气容积(FEV₁)、FEV₁占用力肺活量百分比、动脉氧分压和动脉二氧化碳分压差异均有统计学意义(P<0.01)。结论:雾化吸入盐酸戊乙奎醚能明显改善COPD急性加重期患者的肺功能及动脉血气。

Penehyclidine hydrochloride for treatment of acute exacerbations of chronic obstructive pulmonary disease

Objective ：To investigate the therapeutic effect of penehyclidine hydrochloride on acute exacerbations of chronic obstructive pulmonary, disease （COPD）. Methods：Forty-five patients with COPD were randomly divided into control group and treatment group. The basic regimens for the two groups were oxygen, antibiotics and aminophylline. The treatment group was given misting inhalation of sodium chloride （4 ml ） and penehyclidine hydrochloride （0.5 ml ） twice a day in addition to the routine therapy. The pulmonary function and the arterial blood gas were detected 7 days before and after the therapy. Results：There were no significant differences in pulmonary function or arterial gas blood before treatment between the two groups （ P 〉 0.05 ）. After the therapy, the pulmonary function and the relevant parameters of arterial blood gas improved significantly in the two groups （P 〈 0. 01 ）. The FEV1 , FEV1/FVC, PaO2 and PaCO2 were much higher in the treatment group than in the control group （P 〈 0.01 ）. Conclusions： Inhalation of penehyclidine hydrochloride may efficiently improve the pulmonary function and the arterial blood gas level in patients with acute exacerhations of COPD.