自然流产病人抗ACA和抗DNA抗体分析

目的 :探讨抗心磷脂抗体 (ACA)及抗DNA抗体检测在反复自然流产 (RSA)诊断中的意义。　方法 :应用ELISA法检测 5 6例RSA病人血清ACA与抗DNA ,与对照组 38例比较。　结果 :RSA组ACA、抗ss DNA阳性率分别为 32 .1% (18/ 5 6 )、2 1.4% (12 / 5 6 )较对照组 5 .2 % (2 / 38)、5 .2 % (2 / 38)明显增高 (P <0 .0 1)。三种类别ACA以IgG、IgM型检出率高 ,抗ds DNA阳性率为 3.5 % (2 / 5 6 )。　结论 :ACA及抗ss DNA与RSA密切相关 ,抗ds DNA对诊断RSA无明显意义。

Detection of Anti-Cardiolipin Antibody and Anti-DNA Antibody in 56 Patients with Recurrent Spontaneous Abortion

ObjectivesTo explorethe significance of anticardiolipin antibody(ACA) and anti-DNA antibody in diagnosis ofrecurrent spontaneous abortion(RSA).　MethodsSerum ACA and anti-DNA in 56 patients withRSA were detected with ELISA and compared with those in 38 controls.　ResultsThe positive rates of ACA andanti-ss-DNA in RSA group were 32.1%(18/56) and 21.4%(12/56) respectively, which werenotably higher than those (5.2% and 5.2%) in the control group(P<0.01).The detectablerates of ACA of IgG and IgM types were relatively higher while the positive rate ofanti-ds-DNA was 3.5%(2/56).　ConclusionsACA and anti-ss-DNA were closelyrelated to RSA,while anti-ds-DNA was of no obvious significance in diagnosis of RSA.