| 乙型肝炎患者肝活动指数与血清HBV DNA含量关系初探 |
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| 引用本文： | 焦平华,杨伟,马光. 乙型肝炎患者肝活动指数与血清HBV DNA含量关系初探[J]. 实用肝脏病杂志, 1998, 0(4) |
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| 作者姓名： | 焦平华 杨伟 马光 |
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| 作者单位： | 山东省潍坊市解放军第89医院感染科 261021(焦平华，杨伟)，山东省潍坊市解放军第89医院感染科 261021(马光) |
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| 摘 要： | 为了研究肝组织活动性积分(HAI)与血清HBV DNA含量之间的关系,我们对21例CHB患者行肝穿活检、计算HAI,采用信号引物能量转移定量PCR测定患者血清HBV DNA水平。结果显示随着肝功能损害程度增加,HAI增加、患者血清HBV DNA含量有降低趋势,但均无显著性差别(P>0.05)。结果显示,肝脏组织学损害程度与血清HBV DNA含量无明显相关。血清HBV DNA水平测定并不能准确判断患者病情。
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| 关 键 词： | 乙型肝炎 肝组织学 乙型肝炎病毒核酸 定量PCR |
CORRELATION OF SERUM HBV DNA LEVEL TO HEPATIC HISTOLOGICAL ACTIVITY INDEX IN PATIENTS WITH CHRONIC HEPATITIS B |
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| Jiao Pinhua,Yangwei,Ma guang,et al.. CORRELATION OF SERUM HBV DNA LEVEL TO HEPATIC HISTOLOGICAL ACTIVITY INDEX IN PATIENTS WITH CHRONIC HEPATITIS B[J]. Journal of Clinical Hepatology, 1998, 0(4) |
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| Authors: | Jiao Pinhua Yangwei Ma guang et al. |
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| Affiliation: | Jiao Pinhua,Yangwei,Ma guang,et al.89th hospital of PLA.Weifang,Shandong.261021 |
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| Abstract: | The correlation of serum HBV DNA levels to hepatic histological activity index(HAI)in 21 patients with chronic hepatitis B(CHB) was studied.21 cases of CHB were assessed histologically according to the criteria of Knodell and the serum HBV DNA levels were assessed by a quantitative PCR which is based on ampisensor and energy transfer assay.Our results showed that as the liver injury was aggravated,the serum HBV DNA levels were slightly decreased.However,there is no statistically significance.It is the conclusion that the serum HBV DNA level is not correlated significantly to the degree of liver damage. |
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| Keywords: | Hepatitis B Histology HBV DNA Quantitative PCR |
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