参芪降糖颗粒对2型糖尿病早期下肢动脉粥样硬化性病变的影响

目的 观察参芪降糖颗粒对2型糖尿病(type2 diabetes mellitus,T2DM)早期下肢动脉粥样硬化性病变(lower extremity atherosclerotic disease,LEAD)患者动脉粥样硬化(atherosclerosis,AS)的影响.方法 将患者随机分为两组,治疗组30例口服参芪降糖颗粒,对照组30例口服两洛他唑,3个月为1个疗程,治疗前后分别检测患者下肢血管多普勒超卢、白细胞介素-6(IL-6)水平.结果 治疗组下肢动脉斑块厚度及动脉内中膜厚度较治疗前显著减少(t=3.376、3.468,P<0.05),血清IL-6水平较治疗前显著下降(t=3.345,P<0.05).结论 参芪降糖颗粒可减少斑块厚度、改善动脉内中膜增厚及稳定斑块.

Effect of Shenqi Jiangtang Granule on atherosclerotic changes of lower extremities in patients with early type 2 diabetes mellitus

Objective To observe the effect of Shenqi Jiangtang granule (SJG) on atherosclerotic disease (LEAD) of lower extremity in patients with early type 2 diabetes mellitus (T2DM). Methods The patients were randomly assigned to a control group and a treatment group. 30 patients in the treatment group were treated by SJG and 30 patients in the control group were given Cilostazo. Both groups were treated for 3 months. Lower extremity vascular color Doppler image, blood levels of interleukin-6 (IL-6) were measured before and after the treatment. Results The thickness of atherosclerosis (AS) plaque and arterial media were obviously reduced (t=3.376, 3.468, P<0.05) , serum levels of IL-6 were also be lowered obviously (t=3.345, P<0.05) in the treatment group. While these indexes remained unchanged in the control group. Conclusion SJG has remarkable action in reducing the thickness of AS plaque and media of artery. The mechanism might be related with its reducing serum IL-6 level.