Transmission of Hepatitis C Virus by Anti-HCV-Negative Blood Transfusion: Case Report |
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Authors: | H. Vrielink C.L. vander Poel H.W. Reesink H.L. Zaaijer and P.N. Lelie |
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Affiliation: | Red Cross Blood Bank Amsterdam;Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands |
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Abstract: | Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA-2, were retested by PCR and 3rd-generation antibody tests. One implicated donation was PCR positive, but anti-HCV negative. Both other donations were negative in all tests. The donor was recalled to the Blood Bank 13 weeks after the implicated donation and was found to be ELISA-3 plus RIBA-3 positive. Eight months after the implicated donation, the donor is still PCR and RIBA-3 positive, whereas the recipient became PCR negative but remained anti-HCV RIBA-3 positive. The case shows that blood products from donors collected during the open window period of an HCV infection can transmit HCV to recipients. |
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