龙胆苦苷抗炎药理作用研究

目的 研究秦艽所含龙胆苦苷的抗炎作用。方法 分别用二甲苯致小鼠耳肿胀，冰醋酸致小鼠腹腔毛细血管通透性增加及小鼠扭体反应，酵母多糖A、角叉菜胶、制霉菌素致大鼠或小鼠足跖肿胀模型，ig给药，观察龙胆苦苷的抗炎作用。结果 龙胆苦苷能减轻二甲苯所致小鼠耳肿胀、冰醋酸所致小鼠腹腔毛细血管通透性增加、角叉菜胶、酵母多糖A所致大鼠足跖肿胀，但对制霉菌素所致的炎症模型无明显作用。结论 秦艽所含龙胆苦苷具有一定的抗炎作用，其机制涉及对多种炎症介质的抑制。抗炎作用能部分代表秦艽生药的传统功效。

Studies on anti-inflammatory effect of gentiopicroside

Object To study the anti-inflammatory effect of gentiopicroside extracted from Radix Gentianae Marrophyllae. Methods The models of auricular edema in mice induced by dimeth yl benzene, increased permeability of celiac blood capillary and body-twisting reaction induced by acetic acid, paw swelling induced by zymosan A, carrageenan a nd nystatin in rats or in mice were prepared. Then gentiopicroside was given to the rats or mice by ig. Results Gentiopicroside inhibited th e auri cular edema, decreased the permeability of celiac blood capillary, reduced the p aw swelling induced by carrageenan and zymosan A, but not by nystation. Conclusion Gentiopicroside extracted from Radix Gentianae Marrophyllae, exhibits obvious anti-inflammatory effects.