恶性肿瘤固有荧光初步探讨

本文报道我们应用氮分子激光器和汞灯作为光源,诱发肿瘤组织产生固有荧光的方法和观察结果。本组共观察临床病人25例和手术切除标本14个。用上述光源辐照病人的肿瘤部位时,有20例局部产生桔红色荧光,再取活组织检查,均证实为恶性肿瘤,用专用的检测系统检测、记录其特征峰,峰值为6000～G200。而另5例局部辐照时产生蓝白色光,其峰值为4600～4800,活检诊断为良性肿瘤或慢性炎症。手术标本检测情况与临床病人相似。上述结果表明,癌肿组织经一定的光源激发后产生固有的特征光谱,发出桔红色荧光,与良性肿瘤和慢性炎症有所区别。本研究为恶性肿瘤的早期诊断提供了一个新的方法。本文并对荧光产生的机理,恶性肿瘤固有荧光观察法的优点和光源等问题进行了讨论。

A PRELIMINARY STUDY OF INTRINSIC FLUORESCENCEE OF MALIGNANT TUMOR

In this paper, we reported the method and the results of the intrinsic fluorescence of tumor tissue bring out by using N2-laser and mercury lamp.25 patients and 14 resected specimens were studied.Among the 25 patients, there were 20 cases revealing orange color fluorescence under above lights, and Were confirmed to be malignant by biopsy.The peak wave length of the fluorescenc was between 6000 A and 6200A, while blue-white fluorescenc in normal tissue, benign tumor and chronic inflammation (5 cases)had wave length of 4600 A to 4800 A.The results of 14 resected specimens were similar to those patient's.The cancer tissue will appear a fluorescence of specific spec- trum when excited by appropriate light.It provide a new method for the early diagnosis of malignant tumor.We also discussed the mechanism, the advantages and the light source of the method.