Substantially increased risk of cancer in patients with diabetes mellitus: A systematic review and meta-analysis of epidemiologic evidence in Japan |
| |
| Authors: | Hiroshi Noto Keiichiro Osame Takehiko Sasazuki Mitsuhiko Noda |
| |
| Affiliation: | 1. Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Tokyo 162-8655, Japan;2. National Center for Global Health and Medicine, Tokyo 162-8655, Japan;1. Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China;2. National Center for Anticancer Drugs Clinical Study, Beijing, China;3. Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China;4. Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA;5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;1. University of British Columbia, Vancouver, British Columbia, Canada;2. University of California San Diego, La Jolla, California;3. Ohio State University, Columbus, Ohio;4. Vanderbilt University, Nashville, Tennessee;5. Mayo Clinic, Rochester, Minnesota;6. Mayo Clinic Arizona, Phoenix, Arizona;1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, People''s Republic of China;2. Department of Gynaecology and Obstetrics, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People''s Republic of China;3. Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People''s Republic of China;1. Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT;2. Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT;3. Department of Urology, Yale University School of Medicine, New Haven, CT;4. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT;5. Departments of Neurosurgery and Epidemiology and Biostatistics, University of San Francisco School of Medicine, San Francisco, CA;1. Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan;3. Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan |
| |
| Abstract: | AimsSeveral meta-analyses have shown that diabetes mellitus affects the risk of certain site-specific cancers. However, a meta-analysis on the overall risk of cancer has not yet been performed.MethodsWe performed a search of MEDLINE and the Cochrane Library for pertinent articles (including their references) that had been published as of June 10, 2010. English-language, original observational cohort studies and case-control studies conducted in Japan were included for a qualitative review and a meta-analysis.ResultsA total of 22,485 cancer cases were reported in four cohort studies and one case-control study (with a total of 250,479 subjects). With these five reports, a meta-analysis of the all-cancer risk in both men and women showed an increased risk in subjects with diabetes, compared with nondiabetic subjects (OR 1.70, 95% CI 1.38–2.10). The increase in the risk ratio adjusted for possible confounders was significant in men and borderline in women (adjusted RR 1.25, 95% CI 1.06–1.46 in men; adjusted RR 1.23, 95% CI 0.97–1.56 in women). An analysis of site-specific cancers revealed increased risks for incident hepatocellular cancer (OR 3.64, 95% CI 2.61–5.07) and endometrial cancer (OR 3.43, 95% CI 1.53–7.72).ConclusionsAs is the case in Western countries, Asian people with diabetes have a higher risk of incident cancer than those without diabetes. Cancer prevention and early detection should be important components of diabetes management in light of the exponentially increasing prevalence of diabetes, which has substantial implications in public health and clinical practices. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
