| 99mTc-TRODAT-1显像在帕金森病诊断中应用的研究进展 |
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| 作者姓名： | 王玲 文正伟 唐坤 李焕斌 |
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| 作者单位： | 温州医科大学附属第一医院核医学科 |
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| 基金项目： | 浙江省温州市科技局公益性科技计划项目(Y20170833,SPECT99mTc-TRODAT-1脑显像对不同临床类型帕金森病患者的应用价值研究)。 |
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| 摘 要： | 帕金森病(PD)是最常见的神经退行性疾病之一,发病人数逐年上升。近年来,单光子发射计算机断层(SPECT)99mTc-TRODAT-1多巴胺转运蛋白(DAT)显像已被应用于PD的临床诊断。研究表明,99mTc-TRODAT-1有助于PD的早期诊断和鉴别诊断,并可对PD疾病的严重程度进行判断。另外,基于99mTc-TRODAT-1显像的影像组学和深度学习也对PD的诊断有一定价值。
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| 关 键 词： | 99mTc-TRODAT-1 帕金森病 多巴胺转运蛋白 显像 计算机断层摄影术 |
Research progress of the application of 99mTc-TRODAT-1 imaging in the diagnosis of Parkinson's disease |
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| Authors: | WANG Ling WEN Zhengwei TANG Kun LI Huanbin |
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| Institution: | (Department of Nuclear Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China) |
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| Abstract: | Parkinson's disease(PD)is one of the most common neurodegenerative diseases,and the number of cases is increasing year by year.In recent years,single photon emission computed tomography(SPECT)99mTc-TRODAT-1 dopa?mine transporter(DAT)imaging has been applied to the clinical diagnosis of PD.Studies have shown that 99mTc-TRODAT-1 may contribute to the early and differential diagnosis of PD and can be used to evaluate the severity of PD.In addition,the radiomics and deep learning method based on 99mTc-TRODAT-1 imaging also have certain diagnostic value for PD. |
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| Keywords: | 99mTc-TRODAT-1 Parkinson’s disease dopamine transporter imaging computed tomography |
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