老年阻塞性睡眠呼吸暂停综合征患者房颤发生机制和治疗的研究进展

阻塞性睡眠呼吸暂停(OSA)是老年常见的睡眠呼吸异常综合征。近年研究发现,OSA患者心房颤动(AF)的发生率明显增加,OSA可能通过代谢异常、组织重构、炎症反应和自主神经失衡等机制诱发心房结构改变和电重构,促进AF发生和发展。OSA患者AF的非药物治疗包括持续气道正压(CPAP)通气治疗、神经刺激、口腔装置和悬雍垂腭咽成形术等,药物治疗包括抗心律失常药物、抗炎药物等;OSA的早期发现和积极治疗可降低AF的发生率。

Mechanism and treatment of atrial fibrillation in elderly with obstructive sleep apnea syndrome

Obstructive sleep apnea(OSA)is a common syndrome in the elderly.Recent studies have found that the incidence of atrial fibrillation(AF)in patients with OSA is significantly increased.OSA may induce atrial structural changes and electrical remodeling through metabolic abnormalities,tissue remodeling,inflammatory response and auto?nomic nervous imbalance,so as to promote the occurrence and development of AF.Non drug treatmen of AF in patients with OSA includes continuous positive airway pressure(CPAP),nerve stimulation,oral devices and uvulopalatopharyngo?plasty,while drug treatment includes antiarrhythmic drugs and anti-inflammatory drugs.Early detection and active treat?ment of OSA can reduce the incidence of AF.