| 环孢素对肾移植病人全血化学发光的影响 |
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| 引用本文： | 陈树元 刘世霆. 环孢素对肾移植病人全血化学发光的影响[J]. 中国药理学报, 1998, 19(4): 372-375 |
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| 作者姓名： | 陈树元 刘世霆 |
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| 摘 要： |
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| 关 键 词： | 肾移植 化学发光 环孢素 嗜中性白细胞 |
Effects of ciclosporin on whole blood chemiluminescence of renal transplant patients. |
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| S Y Chen,S T Liu,L B Hou,Z L Chen. Effects of ciclosporin on whole blood chemiluminescence of renal transplant patients.[J]. Acta Pharmacologica Sinica, 1998, 19(4): 372-375 |
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| Authors: | S Y Chen S T Liu L B Hou Z L Chen |
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| Affiliation: | Department of Clinical Pharmacology, Nanfang Hospital, First Military Medical University, Guangzhou, China. chensy@fimmu.edu.cn |
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| Abstract: | AIM: To examine the possible inhibitory role of ciclosporin (Cic) on luminol-dependent chemiluminescence (CL) of whole blood in renal transplant patients. METHODS: Luminol-dependent CL was used to measure active oxygen species generation in respiratory burst of whole blood stimulated by zymosan A. Fluorescence polarization immunoassay was used to monitor the blood concentration of Cic. RESULTS: CL values of Cic group (n = 50) decreased in comparison with those of normal group (n = 10) (P < 0.01). The blood concentration of Cic was negatively related to CL value (P < 0.01). The serum of renal transplant patients directly inhibited respiratory burst of peritoneal macrophages of rats in a concentration-dependent manner. CONCLUSION: Cic inhibits the phagocytic activity of neutrophils in renal transplant patients. |
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