| 卡托普利对肾血管性高血压大鼠血小板胞浆[Ca^2＋]i及血浆TXA2／PGI2… |
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| 引用本文： | 魏向荣 胡莲. 卡托普利对肾血管性高血压大鼠血小板胞浆[Ca^2＋]i及血浆TXA2／PGI2…[J]. 中国药理学报, 1998, 19(1): 89-91 |
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| 作者姓名： | 魏向荣 胡莲 |
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| 摘 要： |
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| 关 键 词： | 卡托普利 肾血管性高血压 血小板 胞浆 TXA2 |
Effect of captopril on platelet cytosolic [Ca2+]i and plasma TXA2/PGI2 in renovascular hypertensive rats] |
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| X R Wei,L Hu,J Du. Effect of captopril on platelet cytosolic [Ca2+]i and plasma TXA2/PGI2 in renovascular hypertensive rats][J]. Acta Pharmacologica Sinica, 1998, 19(1): 89-91 |
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| Authors: | X R Wei L Hu J Du |
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| Affiliation: | Department of Cardiology, Zhujiang Hospital, Guangzhou, China. |
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| Abstract: | AIM: To study the effect of captopril (Cap) on platelet cytosolic free calcium concentration ([Ca2+]i), platelet aggregation (PAg), and plasma TXA2/PGI2 ratio in the renovascular hypertensive rats. METHODS: Blood pressure was measured once a week by tail-cuff microphonic manometer. Platelet [Ca2+]i was measured by Fura 2-AM. Plasma angiotensin II (Ang), thromboxane A2 (TXA2), and prostacycline (PGI2) were measured by radioimmunoassay. RESULTS: Platelet [Ca2+]i and PAg increased (P < 0.01), while plasma Ang and TXA2/PGI2 ratio elevated (P < 0.05) in the renovascular hypertensive rats; platelet [Ca2+]i and plasma TXA2/PGI2 ratio reduced markedly after i.g. Cap 100 mg.kg-1.d-1 compared with saline for 2 wk. CONCLUSION: The altered TXA2/PGI2 after Cap treatment contributed to the improvement of the platelet [Ca2+]i and PAg. |
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