| 性激素对豚鼠心室乳头状肌动作电位和收缩的影响 |
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| 引用本文： | 张翼 郝永昌. 性激素对豚鼠心室乳头状肌动作电位和收缩的影响[J]. 中国药理学报, 1998, 19(3): 248-250 |
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| 作者姓名： | 张翼 郝永昌 |
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| 摘 要： |
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| 关 键 词： | 雌二醇 睾酮 孕酮 乳头状肌 动作电位 心肌收缩 |
Effects of sex hormones on action potential and contraction of guinea pig papillary muscle. |
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| Y Zhang,Y C Hao,L L Song,S M Guo,S Z Gu,S G Lu. Effects of sex hormones on action potential and contraction of guinea pig papillary muscle.[J]. Acta Pharmacologica Sinica, 1998, 19(3): 248-250 |
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| Authors: | Y Zhang Y C Hao L L Song S M Guo S Z Gu S G Lu |
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| Affiliation: | Department of Physiology, Hebei Medical University, Shijiazhuang, China. henryzha@summ.shcnc.ac.cn |
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| Abstract: | AIM: To study the effects of sex hormones, estradiol (Est), progesterone (Pro) and testosterone (Tes) on the action potential (AP) and contraction of guinea pig papillary muscle. METHODS: Using conventional glass microelectrode and mechanical recording of myocardial contraction. RESULTS: Est slowed down the maximal rate of rise of phase 0 (Vmax) of AP at low concentration (1 mumol.L-1). At 10 mumol.L-1 and above, Est also prolonged AP duration (APD50 and APD90), effective refractory period (ERP) and decreased the maximal isometric tension (Pmax) and velocity of tension development (dT/dt) of contraction. Tes (100 mumol.L-1 - 1 mmol.L-1) prolonged APD90 and ERP with decreased Pmax and dT/dt. But Pro (1 mumol.L-1 - 1 mmol.L-1) had no effects on both AP and contraction. CONCLUSION: Est prolonged AP and depressed contraction of guinea pig papillary muscle. |
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