| 青蔼素阻断豚鼠心室肌细胞活化和缓慢活化的钾电流 |
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| 引用本文： | 杨宝锋 罗大力. 青蔼素阻断豚鼠心室肌细胞活化和缓慢活化的钾电流[J]. 中国药理学报, 1998, 19(3): 269-272 |
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| 作者姓名： | 杨宝锋 罗大力 |
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| 摘 要： |
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| 关 键 词： | 青蒿素 抗心律失常药 钾通道 电生理学 |
Artemisinin blocks activating and slowly activating K+ current in guinea pig ventricular myocytes. |
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| B F Yang,D L Luo,L H Bao,Y C Zhang,H Z Wang. Artemisinin blocks activating and slowly activating K+ current in guinea pig ventricular myocytes.[J]. Acta Pharmacologica Sinica, 1998, 19(3): 269-272 |
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| Authors: | B F Yang D L Luo L H Bao Y C Zhang H Z Wang |
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| Affiliation: | Department of Pharmacology, Harbin Medical University, China. Yangbf@Ems.hrbmu.edu.cn |
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| Abstract: | AIM: To study the effect of artemisinin (Art) on outward rectifier potassium current in ventricular myocytes. METHODS: In isolated guinea pig ventricular myocytes, the effects of Art on the two components of delayed outward rectifier K+ current (IK), the rapidly activating inward K+ current (IKr), and the slowly rectifying outward K+ current (IKs) were observed by the whole cell patch-clamp technique. RESULTS: Art decreased IK in a concentration-dependent manner. The IKstep and IKtail were reduced from 387 +/- 46 pA to 240 +/- 48 pA and from 299 +/- 30 pA to 130 +/- 38 pA, respectively at holding potential of +40 mV by Art 50 mumol.L-1. The envelope of tail analysis suggested that both IKr and IKs were inhibited. CONCLUSION: Art blocked the two components of delayed outward rectifier K+ current (IKr and IKs) in guinea pig ventricular cells. |
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