| cGMP介导以注入L—精氨酸诱导的大鼠血管加压素释放效应 |
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| 引用本文： | 曹鲁乡 沈锷. cGMP介导以注入L—精氨酸诱导的大鼠血管加压素释放效应[J]. 中国药理学报, 1998, 19(5): 459-462 |
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| 作者姓名： | 曹鲁乡 沈锷 |
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| 摘 要： | 目的：探讨ｃＧＭＰ是否介导Ｌ－精氨酸（一氧化氮合酶物）引起的血管加压素（ＡＶＰ）释放增多效应。方法：用放射免疫法测定大鼠血浆中ＡＶＰ水平。结果：侧脑室分别注射Ｌ－精氨酸和８－溴－ｃＧＭＰ（一种可透过膜的ｃＧＭＰ衍生物）能刺激血浆ＡＶＰ水平增加［分别从（３．２±０．５）升至（５．８±１．４）ｎｇ·Ｌ＾－１，从（２．６±０．３）升至６６．６±０．４）ｎｇ·Ｌ＾－１，Ｐ〈０．０１］，同时注射Ｌ－精氨酸和
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| 关 键 词： | 一氧化氮 精氨酸加压素 精氨酸 cGMP |
Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats. |
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| L X Cao,E Shen. Intracerebroventricularly injected L-arginine-induced vasopressin release is mediated by cGMP in rats.[J]. Acta Pharmacologica Sinica, 1998, 19(5): 459-462 |
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| Authors: | L X Cao E Shen |
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| Affiliation: | Shanghai Brain Research Institute, Chinese Academy of Sciences, China. |
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| Abstract: | AIM: To study the possible role of cGMP in the effect of L-arginine-induced arginine-vasopressin (AVP) release. METHODS: In anesthetized rats, saline, L-arginine, 8-Br-cGMP, L-arginine + methylene blue (an inhibitor of guanylyl cyclase) were injected intracerebroventricularly (icv) and the plasma vasopressin level was detected with radioimmunoassay. RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P < 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level. CONCLUSION: cGMP was a mediator of the effect of L-arginine-induced AVP release. |
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