| 吲哚美辛对大鼠和兔关节损伤的影响 |
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| 引用本文： | 王斌 姚余有. 吲哚美辛对大鼠和兔关节损伤的影响[J]. 中国药理学报, 1998, 19(1): 70-73 |
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| 作者姓名： | 王斌 姚余有 |
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| 摘 要： |
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| 关 键 词： | 吲哚美辛 佐剂性 关节炎 白细胞介素 药物副作用 |
Effects of indomethacin on joint damage in rat and rabbit. |
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| B Wang,Y Y Yao,M Z Chen. Effects of indomethacin on joint damage in rat and rabbit.[J]. Acta Pharmacologica Sinica, 1998, 19(1): 70-73 |
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| Authors: | B Wang Y Y Yao M Z Chen |
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| Affiliation: | Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China. |
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| Abstract: | AIM: To study the effects of indometacin (Ind) on joint damages. METHODS: The volume of noninjected hind paw and interleukin-1 (IL-1) production from peritoneal macrophages and articular synoviocytes induced by lipopolysaccharides were assayed in adjuvant arthritis (AA) rats. Measurements of synovial fibroblast proliferative response and proteoglycan synthesis of cartilage from rabbits were used. RESULTS: The secondary inflammatory reactions in AA rats on d 18, 21, and 24 were suppressed by i.g. Ind 2 mg.kg-1.d-1 for 9 d. Ind promoted IL-1 production from both macrophages and synoviocytes in AA rats. Ind 10 mumol.L-1 enhanced the proliferation of rabbit synovial fibroblasts and suppressed the proteoglycan synthesis of articular cartilage in response to IL-1 in vitro. CONCLUSION: Ind is unfavorable to the repair of joint destruction. |
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