| 普鲁卡因胺在体外对兔血小板聚集和血栓素B2生成的抑制作用 |
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| 引用本文： | 单春文 林继红. 普鲁卡因胺在体外对兔血小板聚集和血栓素B2生成的抑制作用[J]. 中国药理学报, 1998, 19(2): 164-166 |
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| 作者姓名： | 单春文 林继红 |
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| 摘 要： | 目的：研究普鲁卡因胺（ＰＡ）对凝血酶诱导血小板聚集和血栓素Ｂ２（ＴＸＢ２）产生的影响。方法：用比浊法和放射免疫分析法．结果：普鲁卡因胺８．５，３４，１３６和５４４μｍｏｌ·Ｌ＾－１有明显抑制作用。抑制率分别为４５％±３７％、１４８％±３２％，８８％±２３％，９２％±１５％和５３％±２４％，６５％±２６％，９０％±６％，９５％±６％。ＰＡ的浓度与血小板聚集和ＴＸＢ２产生的抑制效力之间，以及血小板聚集
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| 关 键 词： | 普鲁卡因胺 血小板聚集 血栓素B2 |
Inhibitory effects of procainamide on rabbit platelet aggregation and thromboxane B2 production in vitro. |
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| C W Shan,J H Lin,Y H Jin. Inhibitory effects of procainamide on rabbit platelet aggregation and thromboxane B2 production in vitro.[J]. Acta Pharmacologica Sinica, 1998, 19(2): 164-166 |
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| Authors: | C W Shan J H Lin Y H Jin |
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| Affiliation: | Department of Pharmacology, First Military Medical University, Guangzhou, China. |
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| Abstract: | AIM: To study the influences of procainamide (PA) on thrombin-induced rabbit platelet aggregation and thromboxane B2 (TXB2) production in vitro. METHODS: Turbidimetry and radioimmunoassay were used. RESULTS: PA 8.5, 34, 136, and 544 mumol.L-1 inhibited thrombin-induced platelet aggregation and TXB2 production, and the inhibitory rates were 45% +/- 37%, 48% +/- 32%, 88% +/- 23%, 92% +/- 15% and 53% +/- 24%, 65% +/- 26%, 90% +/- 6%, 95% +/- 6%, respectively. There was positive correlation between PA concentration and efficiency of inhibition of platelet aggregation and TXB2 production, and also between the inhibition % of platelet aggregation and that of production of TXB2. The three linear equations and main parameters were Y = 0.2075X-4.9157, r = 0.9985; Y = 0.9546X-34.6724, r = 0.9921; Y = 0.8202X + 19.7062, r = 0.9921. CONCLUSION: PA inhibited thrombin-induced platelet aggregation and TXB2 production in rabbits. |
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