| 曲匹地尔阻抑内皮素—1诱导的培养大鼠主动脉平滑肌细胞增生 |
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| 引用本文： | 程焰 龚培力. 曲匹地尔阻抑内皮素—1诱导的培养大鼠主动脉平滑肌细胞增生[J]. 中国药理学报, 1998, 19(3): 254-256 |
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| 作者姓名： | 程焰 龚培力 |
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| 摘 要： |
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| 关 键 词： | 曲匹地尔 内皮素 胸主动脉 血管平滑肌 增生 |
Inhibitory effect of trapidil on proliferation of cultured rat aortic smooth muscle cells induced by endothelin-1. |
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| Y Cheng,P L Gong,F D Zeng,X H Liu,J Y Su,C S Tang. Inhibitory effect of trapidil on proliferation of cultured rat aortic smooth muscle cells induced by endothelin-1.[J]. Acta Pharmacologica Sinica, 1998, 19(3): 254-256 |
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| Authors: | Y Cheng P L Gong F D Zeng X H Liu J Y Su C S Tang |
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| Affiliation: | Institute of Clinical Pharmacology, Tongji Medical University, Wuhan, China. chenyan@public.wh.hb.cn |
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| Abstract: | AIM: To study the effect of trapidil (Tra) on endothelin-1-induced proliferation of cultured rat aortic vascular smooth muscle cells (VSMC). METHODS: The [3H]TdR incorporation into DNA assay, the number of VSMC, and cell cycle distribution were measured. RESULTS: Pretreated with endothelin-1 100 nmol.L-1, cell number, [3H]TdR uptake, and cell mitogenic activity increased 134% +/- 23%, 210% +/- 70%, and 86% +/- 18%, respectively. This proliferation was inhibited by Tra 5, 50, 500 mumol.L-1. The inhibitory rates were 12%-48%, 35%-54% and 15%-47%, respectively. Tra did not influence the proliferation of VSMC without endothelin-1 pretreatment. CONCLUSION: Tra antagonized the proliferation of VSMC induced by endothelin-1. |
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