The DXS423E gene in Xp11.21 escapes X chromosome inactivation |
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| Authors: | Brown, Carolyn J. Miller, Andrew P. Carrel, Laura Rupert, Jim L. Davies, Kay E. Willard, Huntington F. |
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| Affiliation: | 1Department of Genetics and Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland Cleveland, OH 44106 2Department of Genetics, Stanford University Stanford, CA 94305, USA 3Molecular Genetics Group, Institute of Molecular Medicine, John Radcliffe Hospital Headington, Oxford OX3 9DU, UK |
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| Abstract: | The DXS423E gene has been localized to Xp11.21 and is expressedin somatic cell hybrids retaining either the human active orinactive X chromosome, demonstrating that DXS423E escapes Xchromosome inactivation. The XE169 (DXS1272E or SMCX) gene thatescapes X chromosome Inactivation is also located in Xp11.2111.22and maps within the same YAC as DXS423E. Thus the DXS423E andXE169 genes define a new region in the proximal short arm ofthe X chromosome that is not subject to X chromosome inactivation,supporting a regional basis for escape from inactivation. |
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