E—cadherin蛋白表达与非小细胞肺癌患者临床病理特征及预后的联系

目的探讨E-cadherin蛋白在非小细胞肺癌（NSCLC）患者肿瘤组织中的表达与NSCLC吸烟状况、临床病理特征及预后的关系。方法应用免疫组化方法检测112例NSCLC肿瘤组织中E-cadherin的表达，并分析其与NSCLC患者吸烟状况、临床病理特征及预后的关系。结果E-cadherin蛋白在肺腺癌及肺鳞癌组织中均有表达，但吸烟者肺腺癌及肺鳞癌组织中E—cadherin蛋白表达比不吸烟者下降明显。E-cadherin表达与性别、年龄、肺癌病理类型、肿瘤原发灶状况、远处转移状况及肿瘤分化程度等均无明显关系（P〉0．05），但与患者的区域淋巴结转移状况（N—status）、TNM分期及吸烟状况明显相关（P〈0．05）。Kaplan-Meie生存曲线分析结果显示E-cadherin表达下调的患者，其生存率明显下降。结论在NSCLC中检测E—cadherin表达，对判断NSCLC患者的淋巴结转移趋势、及判断患者预后有重要意义。

Relationship between the expression level of E-cadherin and the clinico pathologic features and prognosis of non-small cell lung cancer patients

Objective To investigate the correlations between the expression of E-cadherin protein in tumor tissue of non-small cell lung cancer(NSCLC) patients and smoking status clinicopathologic features,and prognosis of NSCLC patients.Methods The expression of E-cadherin in 112 cases of NSCLC patients were detected by immunohistochemical assay.To analyze the relationship between smoking status,ckinicopathologic features and the prognosis of NSCLC patients.Results The expression of E-cadherin were detected in adenocarcinoma and squamous cell carcinoma,but decreased in smokers.Immunohistochemistry results showed that the expression levels of E-cadherin were correlated with the regional lymph node metastasis(N-status),TNM stage and smoking status(P<0.05),but not correlated with gender,age,pathological type of lung cancer,cancer primary tumor status,distant metastasis status and tumor differentiation(P>0.05).Kaplan-Meier survival curves showed that patients with E-cadherin down-regulation had a poor prognosis.Conclusion Detection of the expression levels of E-cadherin is important to judge the trend of lymph node metastasis and prognosis in NSCLC patients.