心脉通胶囊对冠心病患者内皮素和降钙素基因相关肽的调节作用

目的探讨心脉通胶囊对冠心病患者缺血心肌的保护作用。方法40例冠心病心肌缺血患者在常规西药治疗基础上随机分为心脉通组(20例，加用心脉通胶囊治疗)，对照组(20例)，观察治疗前后，血浆内皮素(ET)、降钙素基因相关肽(CGRP)含量，心电图ST段和临床症状等变化，并与14名健康人作对比。结果两组患者ET明显高于健康人(P＜0.001)，CGRP变化不明显(P＞0.05)。治疗后(1)两组患者ET及症状计分明显降低(P＜0.01)，ST段明显升高(P＜0.01)，但心脉通组ET、症状计分降低及ST段上升幅度明显大于对照组(P＜0.05～0.01)；(2)常规用药者CGRP变化不明显(P＞0.05)，加用心脉通胶囊者CGRP明显提高(P＜0.01)。结论心脉通胶囊对血管活血因子ET、CGRP起积极调节作用，其良好抗心肌缺血作用与血管内皮保护效应密切相关，为中医对“心有病，从脉起”理论提供了科学依据。

Regulating Effects of Xinmaitong Capsule on Endothelin and Calcitonin Gene-related Peptide in Coronary Heart Disease Patients

to assess the protecting effect of Xinmaitong(XMT)capsule on myocardial ischemia. Methods:40 patients of coronary heart disease with myocardial ischemia were divided randomly into XMT group (20 cases) and control group (20 cases). Conventional western medical therapy was given to both groups and the XMT group received additional XMT treatment. The changes of endothelin (ET) and calcitonin gene-related peptide(CGRP) levels, ST segment of ECG and clinical symptoms after treatment in all the patients were observed. Data of 14 healthy persons were taken as normal control. Results:the ET level of all patients was significantly higher than that of normal control (P＜0.01),and level of CGRP in patients was not different from normal control significantly (P＞0.05).After treatment, results that:(1) The ET levels and the scores of clinical symptoms of both groups decreased significantly (P＜0.01), and ST segment elevated markedly (P＜0.01) as compared with before treatment, and the changes revealed more evident in XMT group in comparison with those of the control group (P＜0.05～0.01)；(2)The level of CGRP was significantly increased in XMT group (P＜0.01) while unchanged in the control group (P＞0.05).Conclusion:There is a regulating effect of XMT on regulatory polypetide. XMT could not only reduce significantly the plasma ET content, but also enhance markedly the production and release of CGRP, so it has a good ati-ischemic effect, which may be closely related with its action on improving the function of vascular endothelial cells and regulating metabolism of ET and CGRP.