| 人体表皮生长因子的生殖毒性研究 |
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| 引用本文： | 许欣欣,陈铁江.人体表皮生长因子的生殖毒性研究[J].泰山医学院学报,1995,16(2):99-102. |
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| 作者姓名： | 许欣欣 陈铁江 |
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| 作者单位： | 广州市中山医科大学卫生学院劳动卫生教研室 |
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| 摘 要： | 我们为新药“人体表皮生长因子”（以下简称ＨＥＧＦ）提供安全使用的科学依据，进行了大鼠致畸敏感毒性试验和小鼠精子畸形成试验。结果表明，ＨＥＧＦ在临床应用液１００倍，２００倍剂量条件下，对孕鼠体重的增长，胚胎早期发育，胎鼠生长发育，骨骼及内脏器官发育等指标均无明显的影响，精子畸形成试验阴性。
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| 关 键 词： | 表皮生长因子 生殖毒理学 表皮 HEGF 药理 |
STUDY ON TOXIC0I0GY OF HEGT TO REPRODUCTIVE SYSTEM |
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| Xu Xinxin,Chen Tiejiang,Zhong Xiaoming.STUDY ON TOXIC0I0GY OF HEGT TO REPRODUCTIVE SYSTEM[J].Journal of Taishan Medical College,1995,16(2):99-102. |
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| Authors: | Xu Xinxin Chen Tiejiang Zhong Xiaoming |
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| Abstract: | In order to furnish scientific evidence for using HEGF safely , the toxity test on sensi- tive period of teratogenesis in rat and sperm teratogenicity test on mouse were carried out. It was found that in the dose of l00 or 200 times more than that to adult person the indexes of the weight gain of pregnant rat,the development of rat fetus,and the development of the skeleton and internal organs of rat fetus were alI not affected significantly.The sperm teratogenicity test was negative. |
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| Keywords: | growth factor reproductive toxicology |
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