| 一氧化氮、一氧化氮合酶在肝硬化门静脉高压症中的研究进展 |
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| 引用本文： | 王金金,黄智铭,王志斌. 一氧化氮、一氧化氮合酶在肝硬化门静脉高压症中的研究进展[J]. 医学综述, 2009, 15(2): 180-182 |
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| 作者姓名： | 王金金 黄智铭 王志斌 |
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| 作者单位： | 1. 温州医学院附属第一医院消化科,浙江温州,325000
2. 温州医院基础医学院,浙江温州,325000 |
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| 摘 要： | 一氧化氮(NO)具有重要的生物活性,与肝硬化门静脉高压症的发生、发展密切相关。一氧化氮合酶(NOS)是NO合成的关键酶,目前一些通过干预NOS来调整局部(如肝脏、内脏血管)NO浓度进行治疗的研究已取得一定的进展,本文就NO、NOS在肝硬化门静脉高压症中的相关研究予以综述,为研究其发病机制和治疗提供新的切入点。
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| 关 键 词： | 一氧化氮 肝硬化 门静脉高压 脾大 |
Research Progress of Nitric Oxide and Nitric Oxide Synthase in Liver Cirrhosis with Portal Hyper-tension |
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| WANG Jin-jin,HUANG Zhi-ming,WANG Zhi-bin. Research Progress of Nitric Oxide and Nitric Oxide Synthase in Liver Cirrhosis with Portal Hyper-tension[J]. Medical Recapitulate, 2009, 15(2): 180-182 |
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| Authors: | WANG Jin-jin HUANG Zhi-ming WANG Zhi-bin |
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| Affiliation: | WANG Jin-jin ,HUANG Zhi-ming , WANG Zhi-bin. ( 1. Department of Digestion, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China; 2. School of Basic Medical Science, Wenzhou Medical College, Wenzhou 325000, China ) |
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| Abstract: | As a crucial bioactive substance,Nitric Oxide （NO） is considered to play a key role in the pathogenesis of portal hypertension of liver cirrhosis. Nitricoxide synthase （NOS） is a key enzyme for NO. Recent researches show that interventional measures on NOS to regulate the local NO concentration, such as the liver and splanchnic vessels,have achieved curative effects. This review was concerned on the differential expression of NOS and its significance among hyperdynamic circulation, cirrhotic liver, splenomegaly and immunalogic derangement, which may shed light on the mechanisms of liver cirrhosis with portal hypertension and be of help to develop new therapies. |
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| Keywords: | Nitric oxide Liver cirrhosis Portal hypertension Splenomegaly |
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