首发偏执型精神分裂症血清NO/NOS水平的研究

目的探讨首发偏执型精神分裂症血清一氧化氮/一氧化氮合成酶（NO/NOS）水平及与精神症状的关系。方法共收集首发偏执型精神分裂症患者26例（研究组）,健康对照者30例（对照组）,采用阳性与阴性症状量表（PANSS）评定患者的精神症状,同时检测血清NO/NOS水平。结果首发偏执型精神分裂症血清NO/NOS水平均显著高于健康对照组（t=2.08,P〈0.05;t=2.72,P〈0.05）,血清NO/NOS水平与精神症状无显著相关性（P〉0.05）;血清NO水平与血清NOS水平两者存在显著正相关（r=0.41,P〈0.05）。结论首发偏执型精神分裂症患者存在血清NO/NOS水平病理性增高。

A study of the serum level of nitric oxide and nitric oxide synthase in first-episode paranoid schizophrenia

Objective To explore the serum level of nitric oxide and nitric oxide synthase in first-episode paranoid schizophrenia and their relationship with clinical symptoms.Methods The serum level of nitric oxide and nitric oxide synthase of 26 first-episode paranoid schizophrenia and 30 normal controls subjects were detected.Clinical symptoms were rated by Positive and Negative Syndromes Scale(PANSS).Results Both the serum level of nitric oxide and nitric oxide synthase of first-episode paranoid schizophrenia were higher than that of normal controls(P<0.05).Both the serum level of nitric oxide and nitric oxide synthase were not correlated with total or Subscale of PANSS(P>0.05).Conclusions There are high serum level of nitric oxide and nitric oxide synthase in first-episode paranoid schizophrenia.