| Notch信号通路与多发性骨髓瘤相关机制研究 |
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| 引用本文： | 杨沛,刘庭波,谢捷明. Notch信号通路与多发性骨髓瘤相关机制研究[J]. 海峡药学, 2012, 24(9): 5-8 |
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| 作者姓名： | 杨沛 刘庭波 谢捷明 |
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| 作者单位： | 1. 福建医科大学附属协和医院 福州350001
2. 福建医科大学 福州350004 |
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| 摘 要： | Notch信号转导通路是一种进化上十分保守的相邻细胞间的相互作用机制,参与了细胞的自我更新、分化、存活以及凋亡等诸多过程,调控着动物组织和器官的发生、发育和再生.研究表明,在胚胎发育过程中起着关键作用的Notch信号通路在多发性骨髓瘤的发生、发展及转移的过程中起决定性作用,弄清MM的发病机制及提高靶向治疗的针对性,防止耐药已成为研究热点.
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| 关 键 词： | Notch信号通路 多发性骨髓瘤 机制 |
Mechanism of the Correlation between Notch Signaling Pathway and Multiple myeloma |
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| YANG Pei , LIU Ting-bo , XIE Jie-ming. Mechanism of the Correlation between Notch Signaling Pathway and Multiple myeloma[J]. Strait Pharmaceutical Journal, 2012, 24(9): 5-8 |
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| Authors: | YANG Pei LIU Ting-bo XIE Jie-ming |
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| Affiliation: | 1.Fujian medical university union hospital,Fuzhou 350001,China;2.Fujian medical university,Fuzhou 350004,China) |
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| Abstract: | Notch signaling pathway was an evolutionarily conserved cell Mechanism that participated in a variety of cellular processes：self-renewal,differentiation,survival,apoptosis.Studies showed that Notch signaling pathway,which played a critical role in the process of embryonic development,mediated the initiation,progression and metastasis of Multiple myeloma（MM）.Identify the MM mechanism and improve the relevance of the targeted therapies have become a hot topics. |
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| Keywords: | Notch signaling pathway Multiple myeloma Mechanism |
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