血液光量子治疗对强直性脊柱炎患者免疫学指标的影响

目的观察血液光量子治疗(UBIO)对强直性脊柱炎(AS)患者免疫学指标的影响,为临床治疗强直性脊柱炎提供参考依据。方法将首次诊断强直性脊柱炎患者45例随机分为单纯服药组(n=22)和服药+UBIO治疗组(n=23),即2个组均常规服用柳氮磺胺嘧啶片,其中1个组在服药基础上给予血液光量子治疗。检测2个组患者的白细胞(WBC)、抗链球菌O(ASO)、C-反应蛋白(CRP)及血沉(ESR),一些相关急病学免疫球蛋白(IgG、IgA、IgM)、补体成分(C3、C4)。结果 2个组患者在治疗1个月后,白细胞升高,ASO、CRP水平及血沉下降,治疗前后组间比较差异均有显著性(P<0.05),组间比较差异无显著性(P>0.05)。治疗2个月和3个月后,服药+UBIO治疗组的WBC计数高于单纯服药组,ASO、CRP、ESR水平低于单纯服药组,差异有显著性(P<0.05)。治疗2个月后,服药+UBIO组IgG为(8.68±1.10)g/L,IgA为(3.10±0.58)g/L,明显低于单纯服药组〔IgG(9.08±1.11)g/L,IgA(3.78±0.58)g/L〕,差异有显著性(P<0.05);IgM、C3、C4水平组间差异无显著性(P>0.05)。治疗3个月后,服药+UBIO组IgG、IgA、IgM、C3、C4水平明显低于单纯服药组,差异均有显著性(P<0.05)。结论血液光量子治疗方法对改善AS患者的免疫功能有一定作用。

EFFECT OF ULTRAVIOLET BLOOD IRRADIATION AND OXYGENATION ON IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH ANKYLOSING SPONDYLITIS

Objective To provide the clinical basis for treatment of ankylosing spondylitis （AS） by observing the effect of ultraviolet blood irradiation and oxygenation （UBIO） on immunological parameters in patients with ankylosing spondylitis. Methods Forty-five patients first diagnosed as ankylosing spondylitis were randomly divided into UBIO treat- ment group （n = 23）and control group（without UBIO, n = 22）. All patients routinely took sulfasalazine tablets. Results ①After UBIO treatment for 1 month, the number of WBC in both UBIO and control group was increased（ P 〈 0.05）, whereas the level of anti-streptolysin O（ASO）, C-reactive protein（CRP）, and erythrocyte sedimentation rate （ESR） was reduced （ P 〈 0.05）. There were no significant differences between the two groups （ P 〉 0.05）. After UBIO treatment for 2 or 3 months, the number of WBC in UBIO treatment group was higher （ P 〈 0.05）, whereas the level of ASO, CRP, ESR was lower（ P 〈 0.05） than in control group. ② After treatment for 2 months, the level of IgG（8.68 ± 1.10） g/L, and IgA （3.10±0.58） g/L in UBIO group was lower than in control group （9.08± 1.11）g/L, and （3.78 ± 0.58）g/L respectively] （P 〈 0.05）, but the level of IgM, C3 and C4 was not significantly different between the two groups （ P 〉 0.05） ; and for 3 months, the level of IgG, IgA, IgM, C3 and C4 was all significantly different between both groups（ P 〈 0.05）. Conclusion Ultraviolet blood irradiation and oxygenation can improve the immune function in patients with ankylosing spondylitis to a certain extent.