| 单纯疱疹Ⅱ型病毒感染对培养的猪主动脉平滑肌细胞形态和LDH释放的影响 |
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| 引用本文： | 徐惠芳,杨小毅,黄红林.单纯疱疹Ⅱ型病毒感染对培养的猪主动脉平滑肌细胞形态和LDH释放的影响[J].心肺血管病杂志,1995(1). |
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| 作者姓名： | 徐惠芳 杨小毅 黄红林 |
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| 作者单位： | 衡阳医学院 |
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| 摘 要： | 病毒感染与动脉粥样硬化之间的关系近年来逐步受到人们重视，本文以培养的猪主动脉平滑肌细胞（ＳＭＣ）为对象，观察了单纯疱疹Ⅱ型病毒（ＨＳＶ－Ⅱ）感染对细胞乳酸脱氢酶（ＬＤＨ）释放及形态的影响。结果显示，ＨＳＶ─Ⅱ感染主动脉平滑肌细胞４８─７２ｈ后，会引起ＳＭＣ出现细胞病变，并且呈滴度依赖性释放乳酸脱氢酶，在高滴度时甚至呈现溶细胞病变。提示长期潜伏存在的疱疹病毒可能作为一种局部损害因子。造成动脉壁平滑肌细胞的损伤。
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| 关 键 词： | 单纯疱疹Ⅱ型病毒（HSV─Ⅱ），猪主动脉平滑肌细胞（SMC），乳酸脱氢酶（LDH） |
Effects of Herpes Simplex Virus Type Ⅱ Infection on Morphology and the Release of Lactate Dehydrogenase in Porcine Aortic Smooth Muscle Cells in Culture |
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| Xu Huifang,YangXiaoyi,Huang Honglin..Effects of Herpes Simplex Virus Type Ⅱ Infection on Morphology and the Release of Lactate Dehydrogenase in Porcine Aortic Smooth Muscle Cells in Culture[J].Journal of Cardiovascular and Pulmonary Diseases,1995(1). |
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| Authors: | Xu Huifang YangXiaoyi Huang Honglin |
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| Abstract: | Herpes viruses have been implicated as etiologic factors in the pathogenesis of human atherosclerosis.In this paper,porcine aortic smooth muscle cells(SMC) in culture were infected with herpes simplex virus type Ⅱ(HSV-Ⅱ).The cytopathic effect(CPE) was observed for 48～72h after infection.There was a significant increase in the release of lactate dehydrogenase(LDH) in HSV-Ⅱ-infected porcine SMC.The results suggested that ubiquitious herper viruses may be one of the injurious agents for inciting atherosclerosis. |
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| Keywords: | Herpes simplex virus typeⅡ Porcine aortic smooth muscle cells Lactate dehydrogenase |
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