碳酸钙混悬液治疗儿童原发性胆汁反流性胃炎的疗效观察

目的观察碳酸钙混悬液治疗儿童原发性胆汁反流性胃炎的疗效。方法2004-10—2006-10，对浙江大学医学院附属儿童医院经胃镜和24h动态胆红素监测仪(Bilitec 2000)确诊为原发性胆汁反流性胃炎的32例患儿，随机分成两组：A组15例，给予碳酸钙混悬液治疗4周；B组17例，给予碳酸钙混悬液加多潘立酮治疗4周，分别于治疗前及治疗2周、4周时观察患儿腹痛、腹胀、恶心、呕吐等症状积分变化，并于治疗4周后停药3d复查胃内24h胆汁反流情况。结果两组治疗4周后各症状积分较治疗前均有明显下降，差异有统计学意义(P<0.05)；两组间治疗后各症状积分下降值比较，差异无统计学意义(P>0.05)。两组患儿治疗4周后24h胃内胆汁反流监测各指标与治疗前相比差异均无统计学意义(均为P>0.05)。结论碳酸钙混悬液对缓解儿童原发性胆汁反流性胃炎症状有明显疗效，但不能有效阻止胆汁反流，合用多潘立酮并无增效作用。

Efficacy of calcium carbonate oral suspension in the treatment of primary bile reflux gastritis in children.

AbstractObjectiveTo evaluate the effect of calcium carbonate oral suspension in the treatment of primary bile reflux gastritis in children.MethodsThirty-two patients diagnosed as primary bile reflux gastritis by endoscopy were confirmed by 24-hour bilirubin monitoring with Bilitec 2000.They were divided into two groups equally at random.All the 15 patients group A were given calcium carbonate oral suspension,while the other 17 patients in group B were treated with calcium carbonate oral suspension and domperidone simultaneously.Dyspepsia symptoms including abdominal pain,abdominal fullness,nausea and vomiting were evaluated before treatment,2 and 4 weeks after treatment.After four weeks of treatment,the 24h gastric bilirubin monitoring was reexamined after three days of out of medicine.ResultsAfter 4 weeks treatment,symptomatic scores were significantly decreased in two groups compared with before treatment(P<0.05).No significant differences of symptomatic scores were observed between two groups before treatment or after treatment(P>0.05).All the parameters of 24-hour gastric bilirubin monitoring were not significantly decreased after 4 weeks of treatment in two groups(P>0.05).ConclusionIt is effective to improve the symptoms of primary bile reflux gastritis in children by use of calcium carbonate oral suspension,although it can’t prevent the reflux of gastric bile.It is helpless to use domperidone in the treatment.