| 黄芩苷水溶性栓剂的制备及体外释放特性研究 |
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| 引用本文： | 朱铁梁,张磊,张莉,赵滨,王薇薇,胡杰,肖斌.黄芩苷水溶性栓剂的制备及体外释放特性研究[J].中国实验方剂学杂志,2010,16(8):1-3. |
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| 作者姓名： | 朱铁梁 张磊 张莉 赵滨 王薇薇 胡杰 肖斌 |
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| 作者单位： | 1. 武警医学院附属医院药剂科,天津,300162
2. 武警医学院药剂学教研室,天津,300162 |
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| 基金项目： | 武警医学院科研课题资助项目 |
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| 摘 要： | 目的:制备黄芩苷水溶性栓剂并进行体外释放研究。方法:熔融法制备黄芩苷水溶性基质栓剂,采用体外溶出试验方法考察栓剂的释放特性。结果:制备的水溶性栓剂硬度、融变时限均符合要求。水溶性栓剂释药速度快,在40min时可达到最大释放,释放符合威布尔分布模型。结论:PEG4000∶PEG400为7∶6的黄芩苷栓剂型较优。
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| 关 键 词： | 黄芩苷 栓剂 聚乙二醇 体外释放 |
| 收稿时间： | 2010/2/26 0:00:00 |
Preparation and Vitro Release Characteristics of Baicalin Water-solubility Suppository |
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| ZHU Tie-liang,ZHANG Lei,ZHANG Li,ZHAO Bin,WANG Wei-wei,HU Jie and XIAO Bin.Preparation and Vitro Release Characteristics of Baicalin Water-solubility Suppository[J].China Journal of Experimental Traditional Medical Formulae,2010,16(8):1-3. |
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| Authors: | ZHU Tie-liang ZHANG Lei ZHANG Li ZHAO Bin WANG Wei-wei HU Jie and XIAO Bin |
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| Institution: | Department of Pharmacy of The Affiliated Hospital;Department of Pharmacy of The Affiliated Hospital;Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force,Tianjin 300162, China;Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force,Tianjin 300162, China;Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force,Tianjin 300162, China;Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force,Tianjin 300162, China;Department of Pharmaceutics, Medical College of Chinese People's Armed Police Force,Tianjin 300162, China |
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| Abstract: | Objective: To prepare baicalin water-solubility suppository and to study and research vitro release of this suppository. Method: To adopt fusion method of preparation of the baicalin suppository and apply vitro dissolution testing to inspect release characteristics of this suppository. Result: Hardness and melt time limit of this suppository are conformed to requirement. this suppository release faster, achieve maximum releasing within 40 minutes and it's releasing consistent with Weibull Distribution Model. Conclusion: This preparation method was easy to operate;the quality was stable and controllable. The excellent ratio of PEG 4000/PEG 400 is 7/6. |
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| Keywords: | baicalin Suppository Polyethylene glycol vitro release |
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