Analyses of chromium and nickel in human pulmonary tissue |
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Authors: | H J Raithel K H Schaller L A Akslen A O Myking O Merkve and A Gulsvik |
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Institution: | (1) Institute of Occupational and Social Medicine and Policlinic for Occupational Diseases, University of Erlangen-Nuremberg, Germany;(2) Department of Pathology, The Gade Institute, University of Bergen, Norway;(3) Department of Thoracic Medicine, University of Bergen, Norway;(4) Institut für Arbeits- und Sozialmedizin der Universit?t, Schillerstrasse 25/29, D-8520 Erlangen, Germany |
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Abstract: | Summary After inhalative occupational exposure to certain compounds containing nickel and chromium (mostly over many years), an accumulation
of these metals may occur in the lung tissue. This is of particular importance, both from a toxicological point of view and
with regard to expert reports, since certain nickel and chromium compounds may induce lung cancers. In the context of this
study, samples of pulmonary tissue from 34 deceased persons from the Bergen area (Norway) were analysed by atomic absorption
spectrometry with regard to their content of chromium and nickel. The deceased comprised 21 men and 13 women. In 15 cases,
death resulted from lung cancer; in the other 19 deceased, there was no indication of a malignant disease of the airways.
The concentrations of nickel found in the lung tissue do not differ between patients with lung cancer and patients with healthy
lungs. On the other hand, the concentration of chromium in the pulmonary tissue in the patients who had died of lung cancer
and who had all been inhalative smokers, are higher (statistically significant) than in the nonsmokers or in those with healthy
lungs. An accumulation of these two metals in the tumor matrix could not be detected. Both the average nickel and the average
chromium concentrations were higher in the persons who had probably been exposed occupationally. Considering the present state
of scientific knowledge, the aspects relevant to expert reports which result from the analyses of metals in the pulmonary
tissue are discussed. |
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Keywords: | Ni- Cr-analyses Human lung tissue Lung cancer Expertise aspects |
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