肺癌患者化疗前后NSE、SIL-2R和TNF测定的临床意义

目的:探讨33例肺癌患者中28人化疗前后血清中NSE、TNF含量的变化。方法:应用放射免疫分析检测33例肺癌患者化疗前后血清NSE和TNF含量,酶联免疫分析测定SIL-2R含量并与30名正常健康人作比较。结果:肺癌患者化疗前血清中NSE、SIL-2R和TNF含量均非常显著地高于正常人组(P<0.01)。化疗后,6个月在未复发的20例中明显下降但仍高于对照组,而复发的8例,其数值又回升至化疗前水平(P<0.05)。结论:检测肺癌患者血清NSE、SIL-2R和TNF含量的变化可作为诊断和疗效观察的参考。

Clinical Significance of Determination of Changes of Serum NSE,SIL-2R and TNF Levels in Patients with Lung Cancer Undergoing Chemotherapy

Objective To detect the changes of serum NSE, SIL-2R and TNF levels in the 33 patients with lung cancer undergoing chemotherapy. Methods Serum NSE, SIL-2R and TNF levels were determined with RIA and SIL-2R levels with ELISA in 33 lung cancer patients both before and after chemotherapy (n=28) as well as in 30 controls. Results Before chemotherapy, serum NSE, SIL-2R and TNF levels in the patients were significantly higher than those in the controls (P<0.01). After chemotherapy, in 20 cases without recurence at 6 months, the levels were much lower but still significantly higher than those in controls (P<0.05). However, in the 8 patients with recurrence, the levels increased again to approaching those before chemotherapy. Conclusion Serum levels of NSE, SIL-2R and TNF might be useful for diagnosis and predicting therapeutic effects after chemotherapy in patients with lung cancer.